1 Referred by Prof. Dr. Salah Deeb Deeb Professor of Pathology, Fac. Vet. Med., Beni Sueif University Prof. Dr. Mahmoud Samy Professor of Pathology, Fac. Vet. Med., Cairo University Pathologic and clinicopathologic studies on chronic copper toxicosis in a group of milking Ewes By Sameh Youssef Dept. of Pathobiology, Ontario Veterinary College, Ontario, Canada *Home address: Dept of Pathology, F...

1. A study has been made of the effects of dietary zinc supplementation on the development of copper toxicosis in three groups each of eight 12-week-old lambs. 2. None of the lambs receiving 420 mg Zn/kg diet developed Cu toxicosis in the 24-week experimental period, compared with three in the control group receiving 43 mg Zn/kg and possibly one in the group receiving 220 mg Zn/kg. 3. Liver Cu ...

Sheep display a variant phenotype with respect to their susceptibility to copper and derivative pathology. The North Ronaldsay sheep are acutely sensitive to environmental copper while the Cambridge breed is much more copper-tolerant. A study of protein expression in the liver of the two different breeds of sheep as a result of copper challenge would aid in the understanding of their differing ...

Sheep of the semi-feral North Ronaldsay (copper-sensitive) and domesticated Cambridge (copper-tolerant) breeds were compared in respect of pathological changes and protein expression in the liver as a result of excessive dietary copper. Acute mitochondrial damage and hepatic stellate cell (HSC) activation with collagen synthesis occurred in response to moderate copper overload in North Ronaldsa...

Zinc salts fed at relatively high concentrations in the diet have been known to produce deleterious effects. Sutton & Nelson (1938) found that 1 % of zinc as carbonate impaired the growth and general health of rats. Smith & Larson (1946) were, however, the first to study extensively this phenomenon in rats. They established that this condition manifested itself in the following two distinct and...

The rates of dissolution of copper, tin, and iron from sintered tungsten-bronze spheres (51.1%W, 44.4%Cu, 3.9%Sn, 0.6%Fe, by mass) were measured in an in vitro simulated avian gizzard at pH 2.0, and 42C. Most of the spheres had disintegrated completely to a fine powder by day 14. Dissolution of copper, tin, and iron from the spheres was linear over time; all r>0.974; all P<0.001. The mean rate ...