An abnormal copper metabolism can cause hepatic copper accumulation and subsequently an increase in oxidative stress. We therefore analyzed the copper metabolism pathways and (non)enzymatic defenses against ROS in three different forms of chronic liver failure in the dog. Chronic hepatitis caused by inherited copper toxicosis (Copper toxicosis, CT) was compared to chronic hepatitis of unknown e...

A lot of studies showed the role of oxidative stress in more than 100 diseases, many neurodegenerative diseases and also in ischemic stroke. Objective: to assess the variation of oxidative stress in the acute phase of ischemic stroke and to find if there is any correlation with the clinical status or with any other biochemical parameter. Methods: We prospectively studied markers of oxidative st...

UNLABELLED In bacteria, copper homeostasis is closely monitored to ensure proper cellular functions while avoiding cell damage. Most Gram-positive bacteria utilize the copYABZ operon for copper homeostasis, where copA and copB encode copper-transporting P-type ATPases, whereas copY and copZ regulate the expression of the cop operon. Streptococcus mutans is a biofilm-forming oral pathogen that h...

Copper films of different thicknesses between 0.2 and 2 microns were electroplated on adhesion-promoting TiW and Ta barrier layers on <100> single crystal 6-inch silicon wafers. The residual stress was measured after each processing step using a wafer curvature technique employing Stoney’s equation. Large gradients in the stress distributions were found across each wafer. Controlled Cu grain gr...

Copper is essential but toxic in excess for aerobic organisms. Yeast transcription factor ACE1 functions as a sensor for copper and an inducer for the transcription of CUP1. In addition, ACE1 can activate the transcription of superoxide dismutase gene (sod1) in response to copper. In this study, we introduced the yeast ACE1 into Arabidopsis and analyzed its function in plant. Under high copper ...

Copper is one of the heavy metal in plant that causes toxicity at high concentration via producing reactive oxygen species. Nitric oxide can protect cells from oxidative stress produce by reactive oxygen species. Effect of different concentrations of copper (1000, 1500 and 2000 μM) and interaction with nitric oxide (100 and 150 μM) were studied on growth parameters (shoot and root length) and s...

The majority of ecotoxicological studies are performed under stable and optimal conditions, whereas in reality the complexity of the natural environment faces organisms with multiple stressors of different type and origin, which can activate pathways of response often difficult to interpret. In particular, aquatic organisms living in estuarine zones already impacted by metal contamination can b...

At high levels, copper in grape mash can inhibit yeast activity and cause stuck fermentations. Wine yeast has limited tolerance of copper and can reduce copper levels in wine during fermentation. This study aimed to understand copper tolerance of wine yeast and establish the mechanism by which yeast decreases copper in the must during fermentation. Three strains of Saccharomyces cerevisiae (lab...

The aim of this study was to identify the effect of Spermine and Salicylic acid on several growth parameters, such as shoot length, shoot fresh and dry weights, amount of protein and carbohydrate, of Badami and Qazvini pistachio cultivated variety under copper stress. The experiment design was completely randomized with three replicates per treatment and four levels of copper (o.5, 30, 45, 60 µ...

Although copper is an essential metal, it is capable of catalyzing the formation of reactive oxygen species that can cause intracellular oxidative damage. We investigated the hypothesis that metal- and oxidative stress-responsive signal transduction pathways mediate the cellular and molecular responses associated with copper exposure. Transient transfection assays using COS-7 cells and mouse me...