Stimulation of astrocytes with epidermal growth factor (EGF) induced proliferation and triggered the biosynthesis of the transcription factor Egr-1, involving the activation of the extracellular signal-regulated protein kinase (ERK) signaling pathway. No differences in the proliferation rate of astrocytes prepared from wild-type or Egr-1-deficient mice were detected. However, expression of a do...

In septic shock, tissue factor (TF) activates blood coagulation, and cytokines and chemokines orchestrate an inflammatory response. In this study, the role of Egr-1 in lipopolysaccharide (LPS) induction of TF and inflammatory mediators in vivo was evaluated using Egr-1(+/+) and Egr-1(-/-) mice. Administration of LPS transiently increased the steady-state levels of Egr-1 mRNA in the kidneys and ...

In order to search for genes that are activated by muscarinic acetylcholine receptors (mAChRs), we used an mRNA differential display approach in HEK293 cells expressing m1AChR. The zinc-finger transcription factor genes Egr-1, Egr-2, and Egr-3 were identified. Northern blot analyses confirmed that mRNA levels of Egr-1, Egr-2, and Egr-3 increased readily after m1AChR stimulation and that a maxim...

In this paper, an experimental investigation on achieving ultra-low emissions in diesel engine was carried out using intake premixed methanol and EGR technology. The influence of introduction method combustion performances were studied comprehensively. results show that NOx (<0.4g/kWh) PM (<10mg/kWh) can be achieved simultaneously dual fuel (DMDF) highly low-temperature mode. Compared wit...

Expression of early growth response (Egr)-1, a transcriptional factor implicated in growth regulation, is suppressed in several malignant tumors. The present study investigated the expression of Egr-1 and related genes in uterine leiomyoma and normal myometrium to determine possible contributions of Egr-1 to neoplastic growth in leiomyoma cells. Levels of Egr-1 transcripts were decreased in all...

Expression of early growth response (Egr)-1, a transcriptional factor implicated in growth regulation, is suppressed in several malignant tumors. The present study investigated the expression of Egr-1 and related genes in uterine leiomyoma and normal myometrium to determine possible contributions of Egr-1 to neoplastic growth in leiomyoma cells. Levels of Egr-1 transcripts were decreased in all...

Ionizing radiation exposure is associated with activation of certain immediate-early genes that function as transcription factors. These include members of jun or fos and early growth response (EGR) gene families. In particular, the functional role of EGR-1 in radiation-induced signaling is pivotal since the promoter of EGR-1 contains radiation inducible CArG DNA sequences. The Egr-1 gene belon...

Detailed hydrogen–air chemical reaction mechanisms were coupled with the three-dimensional grids of an experimental hydrogen internal combustion engine (HICE) to establish a computational fluid dynamics (CFD) model based on CONVERGE software. The effects different modes and emission characteristics HICE under low load studied. simulation results showed that, increase in excess hydrogen, equival...

Vehicle Emission is one of the main causes of environmental damage. Vehicle engines produce carbon dioxide (CO2), hydrocarbon (HC), Nitrogen oxides (NOx) and many other harmful substances. An investigation was conducted using a compression-ignition engine fuelled with different ratios of blends of diesel and biodiesel at different EGR rates. The effects of different ratios of fuel blends and EG...