terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. a novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. a two-layered core tablet composed of a fast release layer made of mannitol, lactose, peg and the drug attached to a sustained release layer co...

a controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. using compritol 888 ato (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. the m...

objective(s) the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. materials and methods microspheres were prepared by water-in-oil-in-oil (w/o1/o2) emulsion-solvent diffusion (esd). a mixed solvent system consisting of acetonitrile and dichloromethane ...

the purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. matrix system was the earliest oral extended release platform for medicinal use. matrix tablets are most commonly used methods to modulate the release profile of drugs. they are much desirable and preferred for such therapy because they offer be...

the present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. nanocapsules of cisplatin containing ethylcellulose have been prepared using solvent evaporation technique under ambient conditions. the prepared nanocapsules were used for controlled drug release of anticancer agents with gold and iron oxide nanoparticles. ...

objective(s): pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. researchers have intended to reformulate drugs so that they may be more safely used in human body. the more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. the aim of t...

in this research, hydrogels based on poly vinyl alcohol and poly acrylic acid blend were prepared which were cross-linked by applied thermal conditions. afterward, effects of time and heating on water uptake were investigated. the highest water uptake value exhibited by the sample that was heated for 20 min. at 110 ºc was about 2129% after 4 days at equilibrium state. hydrogels exhibited ph-sen...

the present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (st-g-pmma and ast-g-pmma) of starch and acetylated starch. drug excipient compatibility was spectroscopically analyzed via ft-ir, which confirmed no interaction between drug and other excipients. formulations were evaluated for physical characteristics like hardness,...