BACKGROUND The objectives of this study were to develop stable cyclosporine A (CsA) ophthalmic micelle solutions for dry-eye syndrome and evaluate their physicochemical properties and therapeutic efficacy. MATERIALS AND METHODS CsA-micelle solutions (MS-CsA) were created by a simple method with Cremophor EL, ethanol, and phosphate buffer. We investigated the particle size, pH, and osmolarity....

worms under the left conjunctiva of a Jewess who had suffered from elephantiasis for four years. An attempt to obtain the worms for examination failed, one disappearing into the tissues during section and the other being lost in the process of extraction in some unaccountable manner. Several members of the patient's family were infected with Wuchereria bancrofti and the presumption is that thes...

More than 50% of the nontypeable (NT) pneumococcal strains received in our laboratory for reference purposes are isolated in sporadic cases of conjunctivitis. To determine the genetic structure of the population of these NT conjunctival strains, we analyzed 75 pneumococci (40 NT and 35 typeable) isolated from conjunctivas and 30 (15 NT and 15 typeable) isolated from other sources. The NT and ty...

We studied the fungal flora of the conjunctival sac in 919 eyes and air-borne fungi between November 1979 and February 1980. Fungi were cultured from 39 of 587 swabs (6.6%) from healthy conjunctivas. This incidence fluctuated with the number of air-borne fungi. The incidence of positive cultures was significantly higher in diseased eyes (32 of 184 eyes; P less than .005). Under ordinary conditi...

We here report the case of a 54-year old patient with a history of appendectomy performed 6 years before and suffering from left lower back pain evolving for 3 months aggravated 3 days before admission to the Emergency Department. Moreover, there was no sign of hematuria or stones emission nor of lumbar or abdominal trauma. On admission physical examination showed fairly good general condition,...

BACKGROUND The Wnt (Wg/Wnt) signaling cascade plays an important role in tumorigenesis. Our previous report indicated that aberrant localization of β-catenin proteins was a feature of pterygia. Therefore, this study aimed to analyze the association of β-catenin protein and expression of a downstream gene, cyclin D1, in pterygial tissues. METHODS Using immunohistochemistry, β-catenin and cycli...

  Chloroma or granulocytic sarcoma (GS) is a malignant neoplasm of myeloid lineage that occur in a variety of anatomic sites other than the bone marrow including soft tissue, bone, lymph node, nasal fossa, skin and sometime in the orbit. In the subconjunctiva it is rarely reported. A 4-year-old girl with a history of treated acute myelogenous leukemia was referred to Farabi Eye Hospital, Tehra...

To evaluate the incidence and characteristics of carriers of conjunctival methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococci (MRCNS) among preoperative patients at an eye clinic, bacterial growth was studied in 978 conjunctival specimens of 628 preoperative patients without signs of ocular infection. Specimens were evaluated for growth ...

PURPOSE Our recent report indicated that tumor suppressor gene (p53) mutations and protein aberrant expression were detected in pterygium. Inactivation of p53 by Human papillomavirus (HPV) 16/18 E6 plays a crucial role in cervical tumorigenesis. In this study, we further speculate that p53 inactivation may be linked with HPV infection in pterygium pathogenesis. To investigate the involvement of...