In our recently published study (1), we describe genetic similarities between conjunctival and cutaneousmelanoma and propose that the treatment rationale for patients with metastasized conjunctival melanoma should be adapted to that for metastasized cutaneous melanoma. Weber and colleagues (2) responded to this, reporting that a BRAF V600E–mutant metastasized conjunctival melanoma patient treat...

Adenosquamous carcinoma (ASC) is a rare form of malignancy which consists of two types of cell, including squamous cells and glandular-like cells. The current report presents the first known case of ASC in the conjunctiva and analyzes the histological findings. A 76-year-old female presented with right eyelid swelling in 2001. A right conjunctival tumor was noted and a biopsy was performed. His...

purpose: to evaluate and compare the results of different surgical methods for post-trabeculectomy bleb revision at labbafinejad medical center, tehran-iran, from 1999 to 2003. methods: this study was conducted on all patients who underwent post-trabeculectomy bleb revision due to hypotony [intraocular pressure (iop) less than 6 mmhg] or bleb leakage. surgical methods were: conjunctival advance...

Background: Conjunctival naevus is a widespread benign eye tumor. Surgical excision or argon laser photocoagulation are treatment choices for superficial and deep conjunctival naevi. Purpose: To compare between surgical photoablation of concerning safety, efficacy post removal complications. Patients & Methods: A randomized controlled trial was conducted in Ophthalmology Department, Al-Azhar Un...

Invasive conjunctival melanoma can arise de novo, from nevus or from melanoma in situ. The literature reports that after treatment of invasive conjunctival melanoma more than 50% of patients develop local tumor recurrence, with 20% eventually requiring orbital exenteration and 20-30% developing fatal metastasis. Our results have improved since we replaced adjuvant cryotherapy with radiotherapy ...

OBJECTIVE To evaluate the predictive value of the seventh edition American Joint Committee on Cancer (AJCC) staging system for conjunctival melanoma. METHODS Retrospective, observational case series of 42 eyes of 42 patients with conjunctival melanoma studied by reviewing medical records, pathology reports, and color photographs. The main evaluated outcomes were demographic information, later...

Ocular melanocytic lesions comprise a spectrum of lesions ranging from benign nevi to invasive melanoma. Clinical and histopathological appearance of conjunctival lesions ranges from freckle to lentigo and to nevi. Between these types, conjunctival nevi and conjunctival melanosis are the most frequent. Conjunctival and uveal melanocytes are derived from the neural crest, as their cutaneous coun...

Objectives To investigate the long-term efficacy and results of surgical management of conjunctival melanoma reconstructed with amniotic membrane transplantation. Materials and Methods Conjunctival melanoma in 10 patients (5 female, 5 male) was totally excised with adjunctive cryotherapy to the surgical margins, corneal epitheliectomy with absolute alcohol in cases of corneal involvement, lam...

Conjunctival melanoma (CM) is an exceptionally rare tumor, with a propensity for local and distant recurrence, with the lungs, skin, liver, and brain being the most common sites of metastasis. Recent progress in systemic treatments, with checkpoint inhibitors and targeted therapies blocking BRAF and MEK, has redefined the standard of care of advanced unresectable and metastatic melanoma. Althou...

Objective To describe the use of subconjuctival administration anti-tumor necrosis factor agent adalimumab for treatment dry eye in patients with Sjögren’s syndrome, and to investigate conjunctival healing. Methods Prospective, nonrandomized, noncomparative interventional case series including consecutive syndrome disease treated subconjunctival adalimumab, who were refractory conventional trea...