Hodgkin lymphoma (HL) is a lymphoid malignancy that is typically derived from germinal-center B cells. EBV infection, mutations in NF-κB pathway genes, and genetic susceptibility are known risk factors for developing HL. CD30 and NF-κB have been identified as potential biomarkers in pediatric HL patients, and these molecules may represent therapeutic targets. Although current risk adapted and r...

PURPOSE To design multichannel large-tip-angle kT-points and spokes radiofrequency (RF) pulses and gradient waveforms for transmit field inhomogeneity compensation in high field magnetic resonance imaging. THEORY AND METHODS An algorithm to design RF subpulse weights and gradient blip areas is proposed to minimize a magnitude least-squares cost function that measures the difference between re...

The objective of this work is to test the hypothesis that increasing the hydrophilicity of DOX-peptide conjugates may modify their entry mechanisms into HL-60 cells from passive diffusion to receptor-mediated uptake. To test this hypothesis, the entry mechanisms and the intracellular disposition of DOX-cIBR7, DOX-PEGcIBR7, FITC-cIBR, and FITC-cIBR7 were evaluated in HL-60 cells. To increase the...

Although frontline treatment of advanced Hodgkin lymphoma (HL) produces high cure rates, disease either will not respond to or will relapse after initial therapy in approximately a quarter of patients. Many patients with disease relapse can be successfully salvaged with second-line chemotherapy followed by autologous stem cell transplantation (ASCT). Patients whose disease relapses after ASCT a...

The excitation k-space perspective on small-tip-angle selective excitation has facilitated RF pulse designs in a range of MR applications. In this paper, k-space-based design of multidimensional RF pulses is formulated as a quadratic optimization problem, and solved efficiently by the iterative conjugate-gradient (CG) algorithm. Compared to conventional design approaches, such as the conjugate-...

INTRODUCTION Most patients with Hodgkin lymphoma (HL) are cured with modern combined modality first-line treatments. Even ~ 50% of patients with relapsed/refractory HL can be cured with high-dose chemotherapy (HDCT) and autologous stem cell transplantation. However, chemotherapy and radiotherapy cause significant acute and long-term side effects and patients relapsing after HDCT have a dismal p...

The HL-LHC upgrade will use deflecting (or crab) cavities to compensate for geometric luminosity loss at low *  and non-zero crossing angle. A local scheme with crab cavity pairs across the IPs is used employing compact crab cavities at 400 MHz. Design of the cavities, the cryomodules and the RF system is well advanced. The LHC crab cavities will be validated initially with proton beam in the ...

Corresponding Author: Farah Fatin Zulkifli Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia (UKM), 43600 Bangi Selangor, Malaysia Email: [email protected] Abstract: This research presents architecture of Ultra Low Power (ULP) Micro Energy Harvester (MEH) using Radio Frequency (RF) signal as an input. RF has many advantages compared to other ambient sour...

This paper presents Artificial Neural Network (ANN) implementation for the Radio Frequency (RF) and Mechanical modeling of lateral RF Micro Electro Mechanical System (MEMS) series micro machined Single pole double through (SPDT) switch. We propose an efficient approach based on ANN for analyzing the losses in ON and OFF state of lateral RF MEMS series switch by calculating the S-parameters. The...