To study human cone phototransduction, the alpha-wave of the ERG was recorded from color normals, dichromats, and patients with retinitis pigmentosa. A model of the activation phase of phototransduction, previously fitted to responses from single rods and the rod alpha-wave, was modified and fitted to the human cone alpha-wave. The modified model fits the cone alpha-wave well and allows questio...

PURPOSE In retinal degenerative diseases, rod photoreceptors typically deteriorate more rapidly than cone photoreceptors. In the Rpe65(-/-) mouse, a model for Leber's congenital amaurosis, cones degenerate much more rapidly than rods. In this model, the retinoid processing pathway in the retinal pigment epithelium is disrupted, and 11-cis retinal is not generated. This study was designed to inv...

The spectral and dynamic properties of cone-driven horizontal cells in carp retina were evaluated with silent substitution stimuli and/or saturating background illumination. The aim of this study was to describe the wiring underlying the spectral sensitivity of these cells. We will present electrophysiological data that indicate that all cone-driven horizontal cell types receive input from all ...

In these notes we investigate the cone of nef curves of projective varieties, which is the dual cone to the cone of pseudo-effective divisors. We prove a structure theorem for the cone of nef curves of projective Q-factorial klt pairs of arbitrary dimension from the point of view of the Minimal Model Program. This is a generalization of Batyrev’s structure theorem for the cone of nef curves of ...

We study the relationship between the parton model and the analysis of light-cone singularities for highly inelastic leptonic processes. For deep inelastic lepton scattering the parton model is found to be a momentum space representation of any model in which free field singularities on the light-cone are dominant. Scaling laws and sum rules derived in one approach are shown to obtain in the ot...

Boynton and Kambe developed a model of chromatic discrimination in which thresholds are mediated by two independent mechanisms: the short-wavelength sensitive (S-) cones (S-cone axis), and the middle-wavelength sensitive (M-) and long-wavelength sensitive (L-) cones (M/L-cone axis). In this study, we used a Maxwellian view optical system to investigate fundamental properties of the model as a f...