background: opioid abuse is common in iran. in recent years, methadone maintenance therapy (mmt) has gained popularity in this country. this study aimed at evaluation concurrent abuse of alcohol in patients under mmt. methods: a predesigned questionnaire was developed and completed after obtaining verbal consent among 49 subjects under mmt in kian rehabilitation centre during january 2014. resu...

-----------------------------DRUG INTERACTIONS--------------------------­ • Atazanavir: Do not co-administer with atazanavir. (7.1) • Drugs with pH-Dependent Absorption: May interfere with the absorption of drugs where gastric pH is important for bioavailability. (7.1) • Warfarin: Concomitant warfarin use may require monitoring for increases in INR and prothrombin time. (7.2) • Tacrolimus: Conc...

Background: To date, studies on methadone overdose in adults have not been ‎reported in Iran. Hence, this study was performed to determine the frequency of ‎methadone overdose and its associated complications in Baharloo Hospital of Tehran ‎between August 2011 and August 2012.‎ Methods: This cross-sectional study was done on 390 cases. All patients with ‎methadone overdoses and positive urine ...

BACKGROUND & AIMS Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB during concomitant use of nonselective (ns)NSAIDs, cyclooxygenase -2 selective inhi...

There are few reports describing the incidence of seizures in patients prescribed a combination clozapine and bupropion for treatment psychiatric disorders, despite known drug-drug interaction associated with concomitant use. We report case 67-year-old geriatric woman who experienced multiple falls while receiving low daily dose 200 mg extended-release (XL) 150 mg. was no recurrence seizure act...

Medication use is extensive in developed countries: it has been estimated that approximately four fifths of US adults use at least one medication (prescription medicine, over-the-counter (OTC) drug, herbal remedy) per week, and this rate increases with age. A recent US survey reported an average of 2.3 medications prescribed or provided per patient visit. A study carried out in Ireland noted th...

Managing patients who present late with HIV infection is challenging. All late-presenting patients should have an individual treatment plan that encompasses both antiretroviral therapy and, where necessary, treatment for opportunistic diseases. Timely initiation of treatment in late presenters is crucial but the optimal time to start therapy depends on many individual factors, including the pre...

drug utilization evaluation (due) is an effective program to identify variability in drug use and to support interventions that will improve patient outcomes. the appropriate use of enoxaparin, a low molecular weight heparin (lmwh), which is widely used as curative or preventive treatment of thromboembolic disorders was assessed in the study. a prospective due was carried out at masih daneshvar...

BACKGROUND There is evidence that the use of any psychotropic and the concomitant use of two or more benzodiazepines are related to an increased risk of fractures in old age. However, also controversial results exist. The aim was to describe associations between the use of a psychotropic drug, or the concomitant use of two or more of these drugs and the risk of fractures in a population aged 65...

BACKGROUND Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin is a rare but serious complication of the use of Nitrofurantoin. CASE PRESENTATION A 72 year old woman taking Nitrofurantoin for recurrent urinary sepsis presenting with breathlessness abdominal discomfort and abnormal liver function tests is described. Drug toxicity secondary to Nitrofurantoin was diagnosed. Ce...