it seems that rapid destruction of gram negative bacteria by antibiotics contributes to the clinical deterioration of some patients with gram negative infections. antibiotics increase the concentration of lipopolysaccharide (lps) in blood and cerebrospinal fluids. released lps can activate blood cells to produce tumor necrosis factor-alpha (tnf-a) and other cytokines. tnf-a appears to be a majo...

the experiment was done in a factorial design based on completely randomized with three factors and five replications in vitro. the first factors, plant extract (nine plant species), the second factor, solvent (5 solvent) and the third factor, concentration (3 concentration) were considered. in pot condition, the experiment was carried out in factorial based on completely randomized design with...