Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease. Thus, the identification of amyloid precursor protein binding proteins involved in regulating processing of amyloid precursor protein by the γ-secretase complex is essential for understanding the mechanisms un...

Transit sequences of chloroplast-destined precursor proteins are phosphorylated on a serine or threonine residue. The amino acid motif around the phosphorylation site is related to the phosphopeptide binding motif for 14-3-3 proteins. Plant 14-3-3 proteins interact specifically with wheat germ lysate-synthesized chloroplast precursor proteins and require an intact phosphorylation motif within t...

In this paper, the mer-Co(NH3)3(NO2)3 complex was used as a new precursor for synthesizing spinel-type cobalt oxide nanoparticles (Co3O4NPs).Thermal decomposition of the complex at low temperature (175 °C) resulted in the Co3O4NPs without using expensive and toxic solvents or complicated equipment. XRD, FT-IR, SEM, EDX, and TEM were employed to characterize the product, and its optical and magn...

The mitochondrial outer membrane contains two translocase machineries for precursor proteins--the translocase of the outer membrane (TOM complex) and the sorting and assembly machinery (SAM complex). The TOM complex functions as the main mitochondrial entry gate for nuclear-encoded proteins, whereas the SAM complex was identified according to its function in the biogenesis of beta-barrel protei...

The thylakoid DeltapH-dependent pathway transports folded proteins with twin arginine-containing signal peptides. Identified components of the machinery include cpTatC, Hcf106, and Tha4. The reaction occurs in two steps: precursor binding to the machinery, and transport across the membrane. Here, we show that a cpTatC-Hcf106 complex serves as receptor for specific binding of twin arginine-conta...

A new chromium(III) complex containing 4ʹ-hydroxy-2,2ʹ:6ʹ,2ʺ-terpyridine (tpyOH) has been prepared by the reaction of CrCl3. 6H2O with tpyOH in the presence of metallic zinc to afford the new complex [CrCl3(tpyOH)] (1). The complex 1 was used as a suitable precursor for the preparation of Cr2O3 nanoparticles by the simple calcination method at three different annealed temperatures of 400, 600, ...

We have studied in vitro cleavage/polyadenylation of precursor RNA containing herpes simplex virus type 2 poly A site sequences and have analyzed four RNA/protein complexes which form during in vitro reactions. Two complexes, A and B, form extremely rapidly and are then progressively replaced by a third complex, C which is produced following cleavage and polyadenylation of precursor RNA. Substi...