TRAIL is a recently described member of the TNF superfamily. The ability of TRAIL to induce apoptosis in a large number of tumors has stimulated interest in TRAIL as a tumor therapeutic agent. Although TRAIL mRNA is expressed in a number of tissues, its functional significance to various organs is unknown. Because tumors rarely develop in the eye, we have examined this organ for functional TRAI...

During locomotion, there is a translation and compensatory rotation of the head in both the vertical and horizontal planes. During moderate to fast walking (100 m/min), vertical head translation occurs at the frequency of stepping (2 Hz) and generates peak linear acceleration of 0.37 g. Lateral head translation occurs at the stride frequency (1 Hz) and generates peak linear acceleration of 0.1 ...

Keeping the finger pointing at an Earth-fixed object during body displacements can be achieved if compensatory arm movements counteract the effect of the rotation on the hand's position in space. Here we investigated the fusion of signals that originated from systems having different neurophysiological properties (i.e., the visuo-oculomotor and vestibular systems) in the production of such comp...

During pursuit of smoothly moving targets with combined eye and head movements in normal subjects, accurate gaze control depends on successful interaction of the vestibular and head movement signals with the ocular pursuit mechanisms. To investigate compensation for loss of the vestibulo-ocular reflex during head-free pursuit in labyrinthine-deficient patients, pursuit performance was assessed ...

BACKGROUND The head-impulse test, which is sensitive and specific for detecting severe unilateral peripheral vestibulopathy, is an accepted part of the neurological examination, especially in patients with vertigo and balance disorders. OBJECTIVE To discover if the head-impulse test is just as useful diagnostically when patients are asked to rotate their own heads, the active head-impulse tes...

During rotational motions, compensatory eye movement adjustments must continually occur in order to maintain objects of visual interest as stable images on the retina. In the present study, the three-dimensional organization of the vestibulo-ocular reflex in pigeons was quantitatively examined. Rotations about different head axes produced horizontal, vertical, and torsional eye movements, whose...

PURPOSE To investigate use of an improved ocular tear film analysis protocol (OPI 2.0) in the Controlled Adverse Environment (CAE(SM)) model of dry eye disease, and to examine the utility of new metrics in the identification of subpopulations of dry eye patients. METHODS Thirty-three dry eye subjects completed a single-center, single-visit, pilot CAE study. The primary endpoint was mean break...

mum quantity of ether followed by chloralose 80 milligrammes per kilogramme body-weight being injected intravenously. The eye cannula, combined with the compensatory manometer without the optical arrangement, made on the lines of Sir Stewart Duke-Elder's manometer (1932), was used throughout. The cat was allowed to settle for two hours after the insertion of the cannula into the eye. The variat...

Sensory experience profoundly shapes neural circuitry of juvenile brain. Although the visual cortex of adult rodents retains a capacity for plasticity in response to monocular visual deprivation, the nature of this plasticity and the neural circuit changes that accompany it remain enigmatic. Here, we investigate differences between adult and juvenile ocular dominance plasticity using Fourier op...

A case of spasmus nutans was studied using objective recordings of head and eye displacement in order to generate a precise description of the ocular oscillations and head nodding and to investigate their interrelationships. The ocularoscillations consisted of 11-Hz sinusoidal convergence movements. The head nodding consisted of a 3-Hz, 3 degrees peak to peak, sinusoidal oscillation in the hori...