C3–N1′ bond formation of bisindoles has been a great challenge due to the intrinsic reactivity indoles as both C3 and N1-nucleophilic character. Herein, we demonstrate an cross-coupling reaction using N-methoxyindoles N-electrophilic indole reagents in presence Lewis acid. The generated this transformation are latent C3-nucleophile, allowing them be used strategic intermediates sequential C3–N1...

c3 typing was performed, by agarose gel electrophorisis, in 147 german patients suffering from hyperlipoproteinemia. the control group consisted of 322 healthy germans. high frequencies of non-typeable sera, varying between 16.66 and 35.71% in different hlp types, found in the present investigation are notable and are a clue for chemical denaturation of c3 protein in hlp patients. statistical a...

We report a dearomative C3-phosphorylation and tandem C3-phosphorylation/aromatization of 2-benzofuryl-ols with P(O)–H species to afford C3-phosphinoyl hydrobenzofurans benzofurans, respectively.