Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin-immunosuppressant complexes, cyclophilin A-cyclosporin A (CyPA-CsA) and FKBP-FK506. How the two structurally distinct immunophilin-drug complexes bind the same target has remained unknown. We report the crystal structure of calcineurin (CN) in complex with CyPA-CsA at 2.8-A resolution. The Cy...

In this paper, we prove some Bernstein type results for n-dimensional minimal Lagrangian graphs in quaternion Euclidean space Hn ∼= R. In particular, we also get a new Bernstein Theorem for special Lagrangian graphs in Cn.

We report the discovery of five cyano derivatives propene towards TMC-1 with QUIJOTE line survey: trans and cis -crotononitrile ( t -CH 3 CHCHCN, c CHCHCN), methacrylonitrile (CH 2 C(CH )CN), gauche -allyl cyanide g CHCH CN CN). The observed transitions allowed us to derive a common rotational temperature 7 ± 1 K for all them. derived column densities are N( CHCHCN) = (5 0.5) × 10 cm −2 , (1.3 ...

The commuting graph of a finite non-abelian group G with center Z(G), denoted by ?c(G), is simple undirected whose vertex set G?Z(G), and two distinct vertices x y are adjacent if only xy=yx. Alwardi et al. (Bulletin, 2011, 36, 49-59) defined the common neighborhood matrix CN(G) energy Ecn(G) G. A called CN-hyperenergetic Ecn(G)>Ecn(Kn), where n=|V(G)| Kn denotes complete on n vertices. Two ...

In this paper we introduce the common minimal equitable and vertex minimal equitable dominating graph and we get characterize the common minimal equitable and vertex minimal equitable dominating graph which are either connected or complete, some new results of these graphs are obtained. Mathematics Subject Classification: 05C70

Let A ∈ Cn be an exceptional extremal copositive n × n matrix with positive diagonal. A zero u of A is a non-zero nonnegative vector such that uTAu = 0. The support of a zero u is the index set of the positive elements of u. A zero u is minimal if there is no other zero v such that supp v ⊂ suppu strictly. Let G be the graph on n vertices which has an edge (i, j) if and only if A has a zero wit...

S FROM OTHER JOURNALS Common cranial nerve disorders in dogs and cats 2. CN V and CN VII ..................................................................607 Pain associated with the sacroiliac joint region: a clinical study of 74 horses....................................................................607

Cryptococcus neoformans (Cn) is a sporeforming, intracellular pathogenic yeast found in soil and other niches worldwide (1). Inhalation of spores is thus extremely common, allowing Cn to infect ~70% of children in urban environments (2). In most cases Cn infections do not present immediate clinical symptoms; rather, Cn is able to enter a chronic latent state that may last for many years by resi...

objective(s): calcineurin (cn) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. the fk-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. to further clarify the role of cn in different stages oflearning and memory the main aim of this study was t...