Two patients with severe combined immunodeficiency and enterovirus infections were successfully treated with pleconaril. There were no adverse affects.

fast fracture is one of the major failure modes in brittle polymers. generally, crack growth in these polymers may occur under combined tensile-shear loading. however, the fracture test data reported previously for some dental restorative resins can not be predicted by using the available fracture criteria.in this paper, a modified fracture criterion is used for estimating the fracture load for...

the invention of polymerase chain reaction (pcr) has been a milestone in the history of biological and medical sciences. the applications of pcr have not only completely revolutionised the research in the field of molecular genetics as well as animal and plant biotechnology, but the technique has also proved its relevance and ingenious utility in other fields of forensic sciences, molecular sys...

background cutaneous leishmaniasis (cl) is an endemic disease in iran. pentavalent antimonials including meglumine antimoniate (ma) are still the gold standard treatment. trichloroacetic acid (tca) is used in treatment of acne scar, photodamaged skin, and some other dermatologic diseases. considering the tca potential to induce collagen synthesis and its efficacy in the treatment of papular cl ...

patients and methods medical records of patients were analyzed retrospectively. results of the six patients, 83.3% (n = 5) were male and 16.7% (n = 1) were female, with a mean age of 2.1 ± 0.49 years. the most common clinical signs were dyspnea (83.3%), fever (66.6%), and vomiting (66.6%). owing to supportive treatments and the combined steroid treatment, respiratory distress diminished and the...

objective(s):electromagnetic radiations which have lethal effects on the living cells are currently also considered as a disinfective physical agent.   materials and methods: in this investigation, silver nanoparticles were applied to enhance the lethal action of low powers (100 and 180 w) of 2450 mhz electromagnetic radiation especially against escherichia coli atcc 8739. silver nanoparticles ...

this study investigated different concepts for natural-gas-fired power plants with the co2capture, and compared them based on the net plant efficiency and emission of co2. the cycles were based ona six oxy-fuel, one post-combustion and two pre-combustion capture concept. this paper presented theresults of an environmental evaluation performed by the application of the life cycle analysis (lca) ...

Despite the first application of gene therapy in 1990, gene therapy has until recently failed to meet the huge expectations set forth by researchers, clinicians, and patients, thus dampening enthusiasm for an imminent cure for many life-threatening genetic diseases. Nonetheless, in recent years we have witnessed a strong comeback for gene therapy, with clinical successes in young and adult subj...

Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on the sharing of a receptor component, the common cytokine receptor γ chain, γ c, which is encoded by the gene mutated in humans with X-linked severe combined immunodeficiency (XSCID). Together, these cytokines play critical roles in lymphoid development, differentiation, growth, and survival as well as med...

It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.