Transforming growth factor beta 1 (TGF-beta 1) switches from an inhibitor of tumor cell growth to a stimulator of growth and invasion during human colon carcinoma progression. We originally observed that metastatic colon carcinoma cells in primary culture responded to TGF-beta 1 by proliferation, whereas moderate to well-differentiated primary site colon carcinomas were growth inhibited by TGF-...

Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and beta-sitosterol (4)], together with the previously isolated individual compounds beta-sitosterol (4), 2,4-di-tert-butylphenol (5), alpha-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentione...

the genus stachys belongs to lamiaceae family with about 300 species and worldwide distribution. in the present study, the cytotoxic activity of four fractions of different satchys species (s. byzatina c. koch., s. inflata benth., s. setifera ten. and s. persica gmel.), has been investigated against ht-29 (colon carcinoma), caco-2 (colorectal adenocarcinoma), t-47d (breast ductal carcinoma) and...

Abstract: A selected series of substituted sulphonamides were synthesized. These compounds were tested for potential antitumor activity against three of human tumor cell lines, Liver carcinoma cell line [HEPG2], Brain tumor cell line [U251] and Colon carcinoma cell line [HCT116]. Cytotoxic activity was assessed by SRB assay. The structures of the resulting compounds have been investigated by el...

Primary squamous cell carcinoma of the colon is extremely rare. The etiology poorly understood, and currently, there are different hypotheses about origin this malignant neoplasm. Here, we r 87-year-old male with a moderately-differentiated nonkeratinizing colon.

results there were 39 cases with lymph node metastasis in 59 malignant tumors, and 0 cases in 6 benign follicular type tumors. the staining scores by jt-95 of the 39 tumors with lymph node metastasis were 5+ in eight cases and 6+ in 31 cases. on the other hand, the scores of 20 malignant tumors without lymph node metastasis were < 4+ in all of the cases. in the co-cultured assay, numerous adhes...

Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and th...

PURPOSE This article investigates the relationship between cancer cells and stromal cells in carcinoma cell living microenvironment and elucidates the mechanism that interleukin-1 receptor antagonist (IL-1RA) blocks metastatic potential in colon cancer. METHODS Western blot and RT-PCR assay were used to determine the expression of hepatocyte growth factor (HGF) and IL-1α in colon carcinoma ce...

Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and th...