In recent years the development ofimproved autoradiographic techniques and in particular electron micro-autoradiography (Caro and von Tubergen 1962) has led to a better understanding of collagen fibre production by fibroblasts (Revel and Hay 1963, Ross and Benditt 1965). It is now generally accepted that collagen fibres are formed outside the cell by an extracellular aggregation of soluble coll...

Three dimensional gels of native type I collagen fibres have been used as a substratum for the growth and migration of Chinese hamster ovary cells (fibroblastoid cell line) and RPMI-3460 melanoma cells (tumorigenic cell line from Syrian hamster). Quantitative data concerning the migration of these cells from the gel surface into the 3-dimensional collagen gel matrix have been obtained. The migr...

One of the limitations of electrospun collagen as bone-like fibrous structure is the potential collagen triple helix denaturation in the fibre state and the corresponding inadequate wet stability even after crosslinking. Here, we have demonstrated the feasibility of accomplishing wet-stable fibres by wet spinning and diacid-based crosslinking of collagen triple helices, whereby fibre ability to...

Suspension culture of single adult rat flexor digitorum brevis (FDB) muscle fibres in Vitrogen, a purified collagen, on tissue culture plastic or glass with mesh ring supports is superior to culture upon other substrates including collagen-, laminin-, or Vitrogen-coated tissue culture plastic. The Vitrogen gel-fibre mixture which attaches to glass or plastic provides at least 10 times more fibr...

Collagen provides cardiovascular tissues with the ability to withstand haemodynamic loads. A similar network is essential to obtain in tissue-engineered (TE) samples of the same nature. Yet, the mechanism of collagen orientation is not fully understood. Typically collagen remodelling is linked to mechanical loading. However, TE constructs also show an oriented collagen network when developed un...

THE description of the microscopic structure of individual trabecular fibres given by Salzmann (1912) has been accepted for many years, and it is only as a result of recent electron microscopic studies that his classical concepts have had to be modified. The principle modification concerns the finer structure of the "clear" zone which lies beneath the trabecular endothelium and surrounds the ce...

Background: Vascular remodelling has recently been shown to be a promising pathogenetic indicator in idiopathic interstitial pneumonias (IIPs). Aim: To validate the importance of the collagen/elastic system in vascular remodelling and to study the relationships between the collagen/elastic system, survival and the major histological patterns of IIPs. Methods: Collagen/elastic system fibres were...

A new material gaining industrial significance for sustainable leather is based on a composite of collagen and zeolite. The zeolite forms 3D network structure covering fibres, improving protein stability creating strength.

Striated fibres showing a beaded appearance in the electron microscope were prepared from the insoluble collagen residue of foetal nucleus pulposus. The assembling and stability of the beaded fibres are controlled to a significant degree by electrostatic forces. In acid solutions (pH 2-0) the organization of the structures is preserved. Analytical data on the preparations show the presence of p...

Received: January 06, 2017; Accepted: January 16, 2017; Published: January 18, 2017 One of the most important components in dentistry is dentine, which is a complex structure with a high organic component. Majority of its organic component is consisted of collagen type I fibres followed by collagen type III, proteoglycans, MMPs and cysteine cathepsins. Thus, dentine can be introduced as one of ...