BACKGROUND Studies on the role of cold agglutinins in the pathogenesis of acute ischemic stroke are scarce. We present a case of an elderly man with acute cerebral infarction probably due to cold agglutinin disease. CASE PRESENTATION On a cold morning, a 71-year-old male of Han nationality with a complaint of sudden onset left-sided weakness and difficulty in speaking was brought to the emerg...

The sera of 8 patients with acquired hemolytic anemia associated with elevated levels of cold agglutinins were studied by various procedures of zone electrophoresis. The agglutinating activity was found associated with proteins of variable mobility in the different cases. The majority represented "fast" gamma-globulins. The 4 sera with the highest titers of cold agglutinins showed distinguishab...

Aim of the case report was to present a rare case of CAD with Malaria. Methods and materials were as per the clinical protocol and investigations done in the department of pathology.Cold Agglutinin Disease (CAD) is a subgroup of autoimmune Haemolytic Anemia (AIHA). Cold reactive immune globulins (agglutinins) which are directed against erythrocyte surface antigen (‘1’ antigen) are essential for...