Citation: Wilkinson TJ, Gould DW, Watson EL and Smith AC (2017) Commentary: Renal Function Estimation and Cockcroft–Gault Formulas for Predicting Cardiovascular Mortality in Population-Based, Cardiovascular Risk, Heart Failure and PostMyocardial Infarction Cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the High-Risk Myocardial Infarction Database Initiatives. Front. Med. 4:77. doi: 10.3389/f...

OBJECTIVE The Cockcroft-Gault and Modification of Diet in Renal Disease (MDRD) equations poorly predict glomerular filtration rate (GFR) decline in diabetic patients. We sought to discover whether new equations based on serum creatinine (the Mayo Clinic Quadratic [MCQ] or reexpressed MDRD equations) or four cystatin C-based equations (glomerular filtration rate estimated via cystatin formula [C...

OBJECTIVE The aim of this study was to compare the estimated glomerular filtration rate (GFR) using the Cockcroft-Gault and the 4-, 5-, and 6-variable Modification of Diet in Renal Disease (MDRD) formulas for digoxin dose adjustment. METHODS Steady-state serum digoxin concentrations were determined in 100 patients with heart failure and normal to severely impaired renal function. Total cleara...

BACKGROUND We estimated the heritability of three measures of glomerular filtration rate (GFR) in hypertensive families of African descent in the Seychelles (Indian Ocean). METHODS Families with at least two hypertensive siblings and an average of two normotensive siblings were identified through a national hypertension register. Using the ASSOC program in SAGE (Statistical Analysis in Geneti...

BACKGROUND Current HIV treatment guidelines recommend using the Cockcroft-Gault equation for drug dosing adjustments. The use of newer glomerular filtration rate (GFR) estimating equations for drug dosing and the appropriateness of physician antiretroviral dosing based on estimated kidney function have not been studied in an HIV-positive population. METHODS We evaluated concordance between me...

BACKGROUND Rapid estimation of the renal function is widely used in clinical practice. METHODS The validity of rapid estimation of renal function as well as long-term changes in renal function from the Cockcroft-Gault formula for estimation of creatinine clearance or from serum creatinine measurements was evaluated against the 51Cr-EDTA plasma clearance technique in 36 type 2 diabetic patient...

Glomerular filtration rate (GFR) is commonly assessed by measurement of endogenous creatinine clearance (Ccr). Several formulae have been described to calculate Ccr from plasma creatinine. I have evaluated the effectiveness of four formulae in 35 healthy subjects (21M and 14F, 18-34 years) and in 41 patients (24M, 17F, 20-69 years) attending a renal clinic with diminished renal function (serum ...

BACKGROUND Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency. OBJECTIVE To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients. METHOD In estimating renal insufficiency in Ghanaian HIV-i...

Introduction: Determination of renal function is particularly important when prescribing antibiotics to elderly patients. This study aims determine the correlation between estimated creatinine clearance and glomerular filtration rate, for a hospitalized population very patients, audit antibiotic errors.Material Methods: Retrospective cohort all patients ? 80 years with antibiotic. Creatinine wa...

OBJECTIVE To test the Mayo Clinic Quadratic (MCQ) equation against isotopic glomerular filtration rate, compared with the Modification of Diet in Renal Disease (MDRD) and the Cockcroft-Gault formulas, in type 2 diabetes. RESEARCH DESIGN AND METHODS Based on values obtained with iothalamate, 118 type 2 diabetic patients were divided into three groups according to renal function: hyperfiltratio...