This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. In-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. Nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared ...

We report a combined experimental and computational study on the critical role of surfactants in the nucleation and growth of Co nanoparticles synthesized by chemical routes. By varying the surfactant species, Co nanoparticles of different morphologies under similar reaction conditions (e.g., temperature and Co-precursor concentration) were produced. Depending on the surfactant species, the gro...

An investigation of the effect of change of total CO(2) concentration from 7 to 43 mM at pH 7.35 in the medium perfusing isolated rat lungs on [U-(14)C]glucose incorporation into lung phospholipids has been carried out. The incorporation of [U-(14)C]glucose into phosphatidylcholine and phosphatidylglycerol of the surfactant fraction and of the remaining lung tissue (residual fraction) was obser...

Piroxicam belongs to BCS class II and has low solubility. Self-nanoemulsifying drug delivery systems (SNEDDS) are considered a potential approach for increasing the solubility release of piroxicam. This study aimed select components component ratios piroxicam SNEDDS using fractional factorial design 26-2 (FFD). The variables used in DFT development type concentration oil (triacetin oleic acid),...

Alveolar epithelium is composed of alveolar epithelial cells of type I (AEC I) and type II (AEC II). AEC II secrete lung surfactant by means of exocytosis. P2X(7) receptor (P2X(7)R), a P2 purinergic receptor, has been implicated in the regulation of synaptic transmission and inflammation. Here, we report that P2X(7)R, which is expressed in AEC I but not AEC II, is a novel mediator for the parac...

Solubility enhancement of antimicrobial drug enrofloxacin has been studied using a series of co-solvents and surfactants. Aqueous solubility of enrofloxacin could be increased up to 26 times. Co-solvents alone produced only small increase in solubility. However, the combined effect of co-solvents and buffer was synergistic and a large increase in solubility could be attained. Ionic surfactants ...

a facile co-precipitation method for the synthesis of well-dispersed ndfeo3 nanocrystals is developed in the presence of octanoic acid as surfactant. co-precipitation can produce fine, high-purity, stoichiometric particles of single and multicomponent metal oxides. the product is characterized by fourier transform infrared spectroscopy (ft-ir), x-ray diffraction (xrd), scanning electron microsc...

calcium carbonate nano-particles were synthesized by a reverse micro-emulsion method at room temperature with tween® 80 and span® 80 as co-surfactants. the nano-particles synthesized were surface modified by stearic acid. an important operating variable in the span 80-tween 80/toluene/water reverse micro-emulsion system, the ω-value (water/surfactant molar ratio) was investigated. the material ...

a topical preparation containing aceclofenac was developed using an o/w microemulsion system. isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (labrasol) and co-surfactant (plurol oleique) for microemulsion formation. five different formulations were formul...

Aiming at improving the stability of Supercritical CO 2 (SC-CO ) foam in high temperature and salinity reservoirs, a kind betaine surfactant, Hexadecyl Hydroxypropyl Sulfo Betaine (HHSB), was screened to stabilize SC-CO foam. The properties were improved elevated pressure. effects surfactant concentration, temperature, pressure on film drainage rate measured explore results showed that an incre...