Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood-brain barrier and the blood-cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficien...

The treatment of central nervous system (CNS) disease has long been difficult due to the ineffectiveness of drug delivery across the blood-brain barrier (BBB). This review summarizes important concepts of the BBB in normal versus pathophysiology and how this physical, enzymatic, and efflux barrier provides necessary protection to the CNS during drug delivery, and consequently treatment challeng...

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

As the people have been suffering from many CNS disorders like Multiple sclerosis, Alzheimer’s disease, Parkinson’s disease many drugs have been developed but they failed in showing the concentration required for action. But nose to brain drug delivery the drug directly enter into the brain. The objective of this review is to provide overview of nose on an physiological, anatomical and, barrier...

One of the unresolved problems on way to improving pharmacotherapy CNS diseases is development and creation technologies that allow drugs cross blood-brain barrier (BBB). The review discusses modern methods drug delivery CNS. advantages disadvantages main pharmacological strategies for directly overcoming BBB an alternative this are shown. New brain with damage (physical, chemical, etc.) withou...

Objective. The main objective of the present investigation was to develop and optimize oral sustained release Chitosan nanoparticles (CNs) of rifampicin by design of experiment (DOE). Methodology. CNs were prepared by modified emulsion ionic gelation technique. Here, inclusion of hydrophobic drug moiety in the hydrophilic matrix of polymer is applied for rifampicin delivery using CN. The 2(3) f...