PURPOSE The analysis of MET gene copy number (CN) has been considered to be a potential biomarker to predict the response to MET-targeted therapies in various cancers. However, the current standard methods to determine MET CN are SNP 6.0 in the genomic DNA of cancer cell lines and fluorescence in situ hybridization (FISH) in tumor models, respectively, which are costly and require advanced tech...

Reduced rank regression (RRR) models with time varying heterogeneity are considered. Standard information criteria for selecting cointegrating rank are shown to beweakly consistent in semiparametric RRR models in which the errors have general nonparametric short memory components and shifting volatility provided the penalty coefficient Cn → ∞ and Cn/n → 0 as n → ∞. The AIC criterion is inconsis...

Isobaric vapor-liquid equilibria of 1-butyl-3-methylimidazolium thiocyanate ([C4C1im][SCN]), 1-butyl-3-methylimidazolium dicyanamide ([C4C1im][N(CN)2]), 1-butyl-3-methylimidazolium tricyanomethanide ([C4C1im][C(CN)3]), and 1-ethyl-3-methylimidazolium tetracyanoborate ([C2C1im][B(CN)4]), with water and ethanol were measured over the whole concentration range at 0.1, 0.07, and 0.05 MPa. Activity ...

Neural coding through inhibitory projection pathways remains poorly understood. We analyze the transmission properties of the Purkinje cell (PC) to cerebellar nucleus (CN) pathway in a modeling study using a data set recorded in awake mice containing respiratory rate modulation. We find that inhibitory transmission from tonically active PCs can transmit a behavioral rate code with high fidelity...

The aim of the present study was to investigate the relationship of MET copy number (CN) and MET mRNA expression to other molecular alterations, clinicopathologic characteristics, and survival of patients with resected non-small cell lung cancer. One hundred fifty-one paired surgical samples of tumor and tumor-distant normal lung tissues were analyzed by comparative quantitative polymerase chai...

For n<105 all coefficients of Fn(x) are ±1 or 0. For n = 10S, the coefficient 2 occurs for the first time. Denote by A w the greatest coefficient of Fn(x) (in absolute value). Schur proved that lim sup -4n= °°. Emma Lehmer proved that An>cn l,z for infinitely many n. In fact she proved that infinitely many such w's are of the form pqr with p, q, and r prime. In the present note we are going to ...

Several approaches for modelling the longitudinal aerodynamic coefficients of a fighter aircraft at high angles of attack, including the unsteady effects are presented. A traditional approach where the model of the coefficient arises in the form of the steady and unsteady effects, the unsteady effect being modelled by means of transfer functions. The second approach uses an internal variable de...

the aromatic plants are rich in essential oils characterized by a notable antimicrobial activity; for this reason, these substances can be used to delay or inhibit the growth of pathogenic or spoilage microorganisms. in this study, log probability percentage (log p%) of growth of the clostridium botulinum type a spores in brain heart infusion (bhi) broth as affected by various levels of zataria...