We report two patients with Beare-Stevenson syndrome. This syndrome presents craniosynostosis with or without clover-leaf skull, craniofacial anomalies, cutis gyrata, acanthosis nigricans, prominent umbilical stump, furrowed palms and soles, genital and anal anomalies. Both female newborn patients presented at birth with craniofacial anomalies, variable cutis gyrata in forehead and preauricular...

Multiple models have been advanced for the evolution of cloverleaf tRNA. Here, the conserved archaeal tRNA core (75-nt) is posited to have evolved from ligation of three proto-tRNA minihelices (31-nt) and two-symmetrical 9-nt deletions within joined acceptor stems (93 - 18 = 75-nt). The primary evidence for this conclusion is that the 5-nt stem 7-nt anticodon loop and the 5-nt stem 7-nt T loop ...

The poliovirus-encoded, membrane-associated polypeptide 2C is believed to be required for initiation and elongation of RNA synthesis. We have expressed and purified recombinant, histidine-tagged 2C and examined its ability to bind to the first 100 nucleotides of the poliovirus 5' untranslated region of the positive strand and its complementary 3'-terminal negative-strand RNA sequences. Results ...

We investigate gravitational lens models for the quadruply-lensed Cloverleaf BAL QSO H1413+1143 based on the HST WFPC/WFPC2 astrometric and photometric data of the system by Turnshek et al. and the HST NICMOS-2 data by Falco et al. The accurate image positions and the dust-extinction-corrected relative amplifications, along with a possible detection of the lensing galaxy in the infrared, permit...

Cloverleaf tRNA with a 75 nucleotide (nt) core is posited to have evolved from ligation of three 31 nt minihelices followed by symmetric internal deletions of 9 nt within ligated acceptor stems. Statistical tests strongly support the model. Although the tRNA anticodon loop and T loop are homologs, their U-turns have been treated as distinct motifs. An appropriate comparison, however, shows that...

The gene for the maturation protein of the single-stranded RNA coliphage MS2 is preceded by an untranslated leader of 130 nt, which folds into a cloverleaf, i.e., three stem-loop structures enclosed by a long distance interaction (LDI). This LDI prevents translation because its 3' moiety contains the Shine-Dalgarno sequence of the maturation gene. Previously, several observations suggested that...

The role of the 5'-untranslated region (5'UTR) in the replication of enteroviruses has been studied by using a series of poliovirus type 3 (PV3) replicons containing the chloramphenicol acetyltransferase reporter gene in which the 5'UTR was replaced by the 5'UTR of either coxsackievirus B4 or human rhinovirus 14 or composite 5'UTRs derived from sequences of PV3, human rhinovirus 14, coxsackievi...

A 69-year-old female underwent an esophagogastroduodenoscopy (EGD) due to a 6-month history of recurrent episode of vomiting. She had been suff ering from rheumatoid arthritis for 20 years, and was under intermittent treatment with non-steroid anti-infl ammatory drugs (NSAIDs). On endoscopic examination, esophagus was normal, and stomach showed mild antral hyperemia. On the anterior wall of the...

Thanatophoric dysplasia (TD) is one the most common lethal skeletal with an incidence of in 20,000. It caused by de novo mutation fibroblast growth factor receptor 3 (FGFR3) which turn leads to reduced proliferation and maturation plate chondrocytes. Two subtypes have been described. Type I typically features short long bones bowed femurs, while type II manifests straighter femurs cloverleaf sk...

We present deep observations of CO(3-2) from the Cloverleaf lensed quasar-starburst at $z=2.56$. discover a 4-5 times less massive companion projected distance 33 kpc host galaxy. The galaxies are connected by bridge CO emission, indicating that they interacting and is being stripped Cloverleaf. also find evidence for fast molecular gas in spectral line may be an outflow induced stellar or quas...