Most clinicians believe that clonidine has minimal abuse potential. Originally introduced as an antihypertensive agent in 1974, clonidine is inexpensive and has well-known and tolerable side effects. In recent years it has been used in a wide variety of clinical situations, including the treatment of opiate dependence and numerous psychiatric disorders in both adults and children. 1 Despite its...

The Department of Anaesthesia at SPMC Bikaner approved the trial and it was carried out during laparoscopic surgery OT with proper informed written permission. study a double-blind, randomised, prospective interventional trial. comprised 60 (ASA) Classes I II patients between ages 18 who were scheduled for elective cholecystectomy. Using computer-generated random number sequence, divided into t...

Postoperative administration of clonidine is an effective treatment for shivering. However, the ability of this drug to stop postanesthetic shivering when administered intraoperatively remains controversial. Furthermore, the relative efficacy of clonidine during isoflurane and propofol anesthesia remains unknown. We therefore evaluated the incidence of postanesthetic shivering in patients given...

Postoperative administration of clonidine is an effective treatment for shivering. However, the ability of this drug to stop postanesthetic shivering when administered intraoperatively remains controversial. Furthermore, the relative efficacy of clonidine during isoflurane and propofol anesthesia remains unknown. We therefore evaluated the incidence of postanestbetic shivering in patients given...

INTRODUCTION Recent studies (Gold et al, 1978; Washton et al, 1980a) showing that the non-opiate antihypertensive agent, clonidine hydrochloride, suppresses signs and symptoms of opiate withdrawal, have suggested that clonidine and similar drugs might be useful in the clinical management of opiate detoxification. The fact that clonidine is not an opiate drug and does not itself produce addictio...

In addition to its centrally mediated hypotensive action, clonidine causes a decrease in intraocular pressure associated with a long-lasting mydriasis. The present study was conducted to determine to what extent this drug-induced pupillary dilation is of central or peripheral origin. Pupil size was observed in cats anesthetized with pentobarbital. Clonidine (1 to 100 mug per kilogram, intraveno...

A report is made of the successful use of oral clonidine for proctalgia fugax by the author on himself. The author, a 30 year old otherwise healthy man, has been having attacks of proctalgia fugax for several years. He had hitherto left the condition untreated. Last year, in a severe attack, he tried oral clonidine 150 micrograms twice a day and found it to be dramatically effective. He was com...

Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 X 10(-6) g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha 2-adrenoreceptor...

Background: Since the number of drug users is increasing, applying a method of detoxification with fewer side effects during withdrawal from opioids and greater reliability seems to be necessary. In addition, without maintenance treatment, there will be limited success of treatment. This study aimed to compare success rates of detoxification with sublingual buprenorphine and clonidine and to ev...