The introduction is equally very clear. It provides a strong clinical rationale for the study, citing relevant literature to highlight the clinical 'problem' to be addressed, and the existing evidence base in this area. The intervention development approach (i.e. MRC guidance, and BCW) is also introduced in sufficient, concise detail for the readership of Implementation Science, who are likely ...

Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade has seen an increasing use of adaptive designs, particularly in drug development. They frequently differ importantly from conventional clinical tri...

1. Methods in Epidemiologic, Clinical and Operations Research–MECOR–program, American Thoracic Society/Asociación Latinoamericana del Tórax, Montevideo, Uruguay. 2. Divisão de Pneumologia, Instituto do Coração – InCor – Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil. 3. Department of Preventive Medicine, Keck School of Medicine, University of Southern...

Q-fever is the generic name for infections mainly occurring as respiratory tract infections with Coxiella burnetii, a obligate intracellular infectious agent belonging to Coxiella genus which is a near relation of Rickettsia family, and its most common type of disease is respiratory infections such as pneumonia and bronchitis. Q-fever has the mortality of 1 to 2%, which is a self-limiting disea...

This paper proposes a machine learning approach to the task of assigning the international standard on classification of diseases ICD-9-CM codes to clinical records. By treating the task as a text categorisation problem, a classification system was built which explores a variety of features including negation, different strategies of measuring gloss overlaps between the content of clinical reco...

In ophthalmology, as in medicine generally, there has been a rapid development of treatment to combat infections and allergic conditions, but the choice of therapy for degenerative, hereditary conditions is-admittedly-just as small as before. The proportionate role played by the genetic degenerative eye lesions as causative factors of blindness, or impaired vision, has thus greatly increased. R...

The purpose of this commentary is to share our evolving clinical experience with the tympanic membrane displacement (TMD) analyzer which has focused on brain pulsatility in nonpulsatile, predominantly centraltype severe disabling subjective idiopathic tinnitus (SIT) patients resistant to attempts for tinnitus relief with instrumentation or medication. One outcome of this evolving TMD experience...