the aim of this study was to evaluate the effects of atorvastatin on negative symptoms in patients with chronic schizophrenia. the study was a prospective, double-blind, 6-week trial. forty patients participated in the study; 19 patients were assigned to the atorvastatin group as well as 21 patients to the placebo group. for assessing negative signs, we used scale for the assessment of negative...

results the findings indicated that ucoc%/oc% was positively and significantly associated with percentage change in max force production during elbow extension (β = 0.28, p = 0.034), however, all other associations were non-significant. background muscles and bones are interconnected. recent studies suggest that undercarboxylated osteocalcin from bone may affect muscle mass and strength. there ...

introduction: palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. the most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local puva. frequently, it is a recalcitrant disease. we investigated the efficacy  and tolerability of the combination of topical calcipotr...

neuroinflammation is a disorder that causes neurological disease. neuroinflammation has a significant role in induce of multiple sclerosis (ms) and one of the situations that must be treated stops the ongoing process of inflammation against the cns by self-reactive lymphocytes. according to the successful results that were obtained from the pre-clinical phase of cell therapy, many studies were ...

dna vaccination has been developed as a noteworthy immunotherapeutic approach for the battle against many serious challenges to human and animal safety, including infectious illnesses, autoimmunity, allergy and cancer. clinical trials prepare chances to examine whether dna vaccines can fulfill their final aim of demonstrating efficiency in treating humans. today, anticancer dna vaccines are qui...

randomization is an essential component of sound clinical trials which prevents selection biases and helps in blinding the allocations. randomization is a process by which subsequent subjects enrolled into trial groups only by chance which is essentially eliminates selection biases. a serious consequence of randomization is severe imbalance among treatment groups with respect to some prognostic...

the aim of this randomized controlled clinical trial was to investigate the effect of a new iranian toothpaste and a commercially available toothpaste containing desensitizing agent (5% potassium nitrate) on dentine hypersensitivity in a 24-week study.fifty healthy volunteers, who had at least two sensitive root surfaces, completed the study period. the participants were randomly given one of t...

background: massive ischemic stroke causes significant mortality and morbidity in stroke patients. the main treatments for massive ischemic stroke are recombinant tissue plasminogen activator (rtpa), craniotomy, and endovascular interventions. due to destructive  effects  of   bradykinin  on  the  nervous system in ischemic stroke, it seems reasonable that using noscapine as a bradykinin antago...