Background. The Global Vascular Guidelines (2019) proposed the term “critical limb-threatening ischemia”, which leads to death or amputation within 12 months. Only half of patients undergo limb revascularization; rest receive conservative treatment, effectiveness is extremely low. In this regard, it necessary develop alternative methods surgical treatment based on use cellular technologies. Aim...

BACKGROUND The Active For Life Year 5 (AFLY5) randomised controlled trial protocol was published in this journal in 2011. It provided a summary analysis plan. This publication is an update of that protocol and provides a detailed analysis plan. UPDATE This update provides a detailed analysis plan of the effectiveness and cost-effectiveness of the AFLY5 intervention. The plan includes details ...

The Patient-Centered Outcomes Research Institute (PCORI) has launched PCORnet, a major initiative to support an effective, sustainable national research infrastructure that will advance the use of electronic health data in comparative effectiveness research (CER) and other types of research. In December 2013, PCORI's board of governors funded 11 clinical data research networks (CDRNs) and 18 pa...

Universal public finance (UPF)-government financing of an intervention irrespective of who is receiving it-for a health intervention entails consequences in multiple domains. First, UPF increases intervention uptake and hence the extent of consequent health gains. Second, UPF generates financial consequences including the crowding out of private expenditures. Finally, UPF provides insurance eit...

A platform for high index-contrast integrated photonics based on tantalum pentoxide submicrometer waveguides on silicon substrates is introduced. The platform allows demonstration of microring resonators with loaded quality factor, Q, of 67,000 and waveguides with a propagation loss of 4.9 dB/cm. Grating couplers, with an insertion loss of ~6 dB per coupler and 3 dB bandwidth of ~50 nm, are als...

Background: Nurse Educators have an important role in clinical learning that can reduce nursing students' stress. However,   a few studies have been conducted on the relationship between nursing students’ tension and clinical educators 'role in such situations, in Iran. The aim of this study is to determine the relationship between nursing students’ stress and perception of nurse educator’s eff...

Due to induced dependent censoring, estimating mean costs and quality-adjusted survival in a cost-effectiveness analysis using standard life-table methods leads to biased results. In this paper we propose methods for estimating the difference in mean costs and the difference in effectiveness, together with their respective variances and covariance in the presence of dependent censoring. We cons...