OBJECTIVE To analyze integrons gene cassettes Class I among Escherichia coli (E. coli) isolates from Sudan and to determine their effect on the prevalence of resistance to antimicrobials. METHODS This cross-sectional study was conducted at 6 hospitals in Khartoum State, Sudan between April and August 2011. Escherichia coli (n=133) isolated from clinical specimens of patients were included. Is...

background: integrons are mobile genetic elements able to obtain the antibiotic resistance gene cassettes. the prevalence of integrons in the enterobacteriaceae family has been varied and played an important role in the development of the drug resistant bacteria. the present study aimed to investigate the contribution of class 2 and 3 integrons in drug resistant diarrheagenic escherichia coli s...

background: ctx-m-type β-lactamases are increasingly becoming the predominant esbls globally in recent years. integrons are genetic elements which can integrate gene cassettes, usually antibiotic resistance genes. objectives: the aims were to determine antibiotic susceptibility and to detect genes encoding ctx-m-1 group enzymes and class 1, 2, and 3 integrons among the klebsiella pneumoniae iso...

OBJECTIVES To study the evolution between 1999 and 2002 and mechanisms of antibiotic resistance in a multidrug-resistant Acinetobacter baumannii clone predominant in isolates from elderly patients with respiratory tract infections. METHODS Susceptibility to antimicrobials was determined using an agar dilution method. Bacterial clones were identified by PCR-fingerprinting and PFGE with ApaI. C...

Introduction: Diffusion of antibiotic resistance genes by horizontal gene transfer has led to the fast emergence of multidrug resistance (MDR) among bacteria. Multiple classes of integrons are effective genetic elements which play a significant role in the acquisition and nosocomial dissemination of resistance factors in strains of Gram-negative bacteria, Pseudomonas aeruginosa, and Acinetobact...

OBJECTIVES To determine the genetic basis for tetracycline and sulphonamide resistance and the prevalence of class I and II integrons in oxytetracycline-resistant Acinetobacter spp. from integrated fish farms in Thailand. METHODS A total of 222 isolates were screened for tetracycline resistance genes [tet(A), tet(B), tet(H), tet(M) and tet(39)] and class II integrons by PCR. One hundred and t...

conclusions high mdr isolates of e. coli were observed in this study. the significant association between class 1 integrons and resistance to ciprofloxacin, nalidixic acid, co-trimoxazole, amoxicillin, ceftazidime and tetracycline showed that class 1 integrons have an important role in resistance to these antibiotics in this region. results the highest rate of resistance was observed toward cep...

BACKGROUND Integrons have a well-established role in the dissemination of resistance among Gram-negative pathogens and are thus a useful marker of antibiotic resistance. Shigellae are noteworthy for their multiple drug resistance, having gradually acquired resistance to most widely use and inexpensive antimicrobial drugs. METHODOLOGY A total of 32 Shigella strains belonging to serotypes flexn...

Integrons are powerful bacterial genetic elements that permit the expression and dissemination of antibiotic-resistance gene cassettes. They contain a promoter Pc that allows the expression of gene cassettes captured through site-specific recombination catalyzed by IntI, the integron-encoded integrase. Class 1 and 2 integrons are found in both clinical and environmental settings. The regulation...