In this study the chemistry of chalcones has generated intensive scientific interest due to their biological and industrial applications. Chalcones are natural biocides and are well known intermediates in the synthesis of heterocyclic compounds exhibiting various biological activities. Chalcones and their derivatives possess some interesting biological properties such as antibacterial, antifung...

Using organic-base tetramethylammonium hydroxide (TMAH) is a viable, cheap, and fast option for the synthesis of MgZnAl-LDH-type materials by both co-precipitation mechano-chemical methods. TMAH presents several advantages, such as smaller quantity water required in washing step compared to use inorganic alkalis, prevention LDH contamination with alkali cations, its action template molecule tex...

Cheap, abundant but seldom-employed Ca(OH)2 was found to be an excellent low-loading (5-10 mol%) catalyst for Claisen-Schmidt condensation of aldehydes with methyl ketones under mild conditions. It was interesting that dilute aqueous ethanol (20 v/v%) was unexpectedly discovered to be the optimal solvent. The reaction was scalable at least to 100 mmol and calcium could be precipitated by CO2 an...

A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The structures of the synthesized chalcones were established by IR and ¹H-NMR analysis. The biological data shows that compounds p₅, f₆ and t₅ had strong activities again...

Solvent-free Claisen-Schmidt reactions of cycloalkanones with various substituted benzaldehydes (aryl aldehydes) using solid NaOH (20 mol%) and applying a grinding technique were studied. Quantitative yields (96-98%) of α,α'-bis-(substituted-benzylidene)cycloalkanones were obtained. Aliphatic aldehydes also provided α,α'-bis-(substituted-alkylidene)cycloalkanones in very good yields with minor ...

Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis performed by using KOH 40% under stirring at room temperature for 48 h. compounds characterized FTIR, GC-MS 1H NMR spectrometers. Further, the chalc...

The synthesis and structural diversification of N-heterocycles systems have attracted much attention because their potential applications. Three 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde 4 derivatives, in reaction with acetophenones 5, via conventional Claisen–Schmidt condensation reactions, generated the respective enones. enones were used as electron-deficient olefins...

UNLABELLED Two efficient reactions were successfully carried out using Animal Bone Meal (ABM) and potassium fluoride or sodium nitrate doped ABMs as new heterogeneous catalysts under very mild conditions. After preparation and characterization of the catalysts, we first report their use in a simple and convenient synthesis of various chalcones by Claisen-Schmidt condensation and then in an aza-...

Sodium acetate catalyzed the multi-component reaction of acetophenone, aromatic aldehydes, and acetoacetanilide in the water-ethanol mixture (1:1) at ambient temperature via Claisen-Schmidt condensation results in the formation of highly substituted cyclohexenones in 89–98% yields. The developed efficient catalytic approach to the substituted cyclohexenones – the promising ...

Aromatic aldehydes are efficiently condensed with 2'-hydroxyacetophenone by polymer-supported basic ionic liquid as an excellent heterogeneous catalyst utilizing the Claisen–Schmidt reaction. Microwave irradiation has been employed, providing flavanone in good yield and short reaction time.