Abstract On the morning of 6 May 2021, military police invaded favela Jacarezinho, one Rio de Janeiro's slums, and killed 28 people during a operation tellingly named Operation Exceptis. Photos dead bodies in alleys denouncements extrajudicial executions individuals who had already surrendered circulated widely on internet. Jacarezinho adds to troubling record killings that includes goes far be...

The generic matrix-matrix multiplication (GEMM) is arguably the most popular computational kernel of the 20th century. Yet, surprisingly, no common methodology for evaluating GEMM performance has been established over the many decades of using GEMM for comparing architectures, compilers and ninja-class programmers. We introduce GEMMbench, a framework and methodology for evaluating performance o...

The lamellipodium is an important structure for cell migration containing branched actin nucleated via the Arp2/3 complex. The formation of branched actin is relatively well studied, but less is known about its disassembly and how this influences migration. GMF is implicated in both Arp2/3 debranching and inhibition of Arp2/3 activation. Modulation of GMFβ, a ubiquitous GMF isoform, by depletio...

Previous two-site immunometric assays for creatine kinase (CK; EC 2.7.3.2) MB isoenzyme have been based on formation of a "sandwich" complex involving CK-MB and antibodies that recognize the CK-MM and the CK-BB isoenzymes. Single-incubation model assays of CK-MB with these antibodies were susceptible to interferences by CK-MM and CK-BB. We produced two anti-CK-MB monoclonal antibodies and studi...

Extracts of normal brains obtained at autopsy and cerebrospinal fluid (CSF) from patients with global brain ischemia were analyzed for creatine kinase (CK; EC 2.7.3.2) isoenzymes. We used both qualitative and quantitative assays (electrophoresis and immunoinhibition). Brain extracts contained CK-BB isoenzyme and mitochondrial CK. In 54 CSF samples free of blood contamination and with total acti...

Intermediate filaments are involved in cell migration and intracellular signal transduction pathways. In a variety of organs, the expression of distinct intermediary filaments are further associated with distinct steps of malignant transformation. In this study, we seeked to define the cytokeratin (Ck) expression pattern in oral leukoplakia and oral squamous cell carcinoma (OSCC). One hundred a...