BackgroundLevels of plasma citrulline (citrulline-P), a biomarker for enterocyte function, might be useful the monitoring course necrotizing enterocolitis (NEC). Our aim was to evaluate whether citrulline-P levels during first 48 h (h) after NEC onset were associated with need surgery, survival, and intestinal recovery.MethodsIn preterm infants (Bell's stage ≥2) we measured onset. Categorizing ...

We read with interest the recent article by Adam et al. (1) suggesting an action of metformin on citrulline metabolism in patients with type 2 diabetes. This study provides compelling evidence that metformin treatment is associated with a decrease in plasma citrulline in these patients and also in multiple tissues in diabetic mice. The authors speculate that high citrulline may be associated wi...

Watermelon (Citrullus vulgaris Schrad.) is a natural and rich source of the non-essential amino acid citrulline. Citrulline is used in the nitric oxide system in humans and has potential antioxidant and vasodilatation roles. A method using gas chromatography-mass spectrometry (GC-MS) was developed to separate citrulline from glutamic acid, which co-elute when analyzed by high performance liquid...

RATIONALE There is evidence that impairments in nitric oxide (NO) signaling contribute to chronic hypoxia-induced pulmonary hypertension. The L-arginine-NO precursor, L-citrulline, has been shown to ameliorate pulmonary hypertension. Sodium-coupled neutral amino acid transporters (SNATs) are involved in the transport of L-citrulline into pulmonary arterial endothelial cells (PAECs). The functio...

OBJECTIVE Arginine supplementation seems logical in situations where this amino acid becomes essential, for example after massive intestinal resection. Arginine is taken up and metabolised by the liver to a large extent and its supplementation is potentially unsafe. Citrulline is not captured by the liver and passes freely to the kidneys where it is metabolised to arginine, and so is a good can...

Watermelon produces many byproducts (watermelon rind and skin) even though those components contain various bioactive compounds, including citrulline. This study evaluated the citrulline concentration, total phenolic content, antioxidant activity (DPPH FRAP assays) of different parts watermelon investigated bioavailability from using an in vitro human intestinal epithelial Caco-2 cell monolayer...

32 33 In enterocytes, glutamine serves as the major source of energy; another metabolic fate of glutamine is 34 conversion to citrulline. Because sepsis can affect gut function and integrity, alterations in glutamine 35 metabolism may exist and lead to decreased citrulline production. This study aimed to investigate how 36 sepsis affects glutamine metabolism, including its conversion to citrull...

INTRODUCTION The role of nitric oxide synthase (NOS) in the pathophysiology of acute respiratory distress syndrome (ARDS) is not well understood. Inducible NOS is upregulated during physiologic stress; however, if NOS substrate is insufficient then NOS can uncouple and switch from NO generation to production of damaging peroxynitrites. We hypothesized that NOS substrate levels are low in patien...

Endothelium injury plays an important role in atherosclerosis. Damage to the endothelium results in vascular smooth muscle cell proliferation. Natriuretic peptides present a potent antimitogenic action, mediating their biological effects via the binding of guanylate cyclase-linked atrial natriuretic peptide (ANP) receptor and the production of cyclic GMP. In a previous study, we demonstrated th...