how to cite this article: ashrafi mr, najafi z, shafiei m, heidari k, togha m. cinnarizinev ersus topiramate in prophylaxis of migraines among children and adolescents: a randomized, double-blind clinical trial. iran j child neurol. 2014 autumn;8(4): 18-27.   abstract objective migraines, a common health problem in children and adolescents, still do not have an fda approved preventive treatment...

Specific stability indicating reverse-phase liquid chromatography (RP-LC) assay method (SIAM) was developed for the determination of cinnarizine (Cinn)/piracetam (Pira) and cinnarizine (Cinn)/heptaminol acefyllinate (Hept) in the presence of the reported degradation products of Cinn. A C18 column and gradient mobile phase was applied for good resolution of all peaks. The detection was achieved ...

Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorlywater-soluble drugs. While increasing the load through thermally-induced supersaturation resulted enhanced vivo exposure for some drugs, others, such cinnarizine, supersaturated have not been found beneficial to increase bioavai...

Drug consumption should be based on the latest pharmacotherapeutic guidelines. However, in Serbia the consumption of so-called drugs with uncertain clinical benefit (pentoxifylline, dihydroergotoxine, nicergoline, deproteinized calf blood extract (DCBE) and cinnarizine) was not in line with the latest pharmacotherapeutic guidelines and was unusually high compared to countries with well develope...

Self-Nanoemulsifying Drug Delivery Systems (SNEDDSs) were developed using well-defined excipients with the objective of mimicking digested SNEDDSs without the use of enzymes and in vitro lipolysis models and thereby enabling studies of the morphology and size of nanoemulsions as well as digested nanoemulsions by Cryo-TEM imaging and Dynamic Light Scattering. Four SNEDDSs (I-IV) were developed. ...

The high performance liquid chromatography for the determination of cinnarizine in human plasma is described. The procedure involves liquid-liquid extraction followed by reversed phase high-performance chromatographic analysis with fluorometric detection. The method was validated for accuracy, precision, specificity, linearity, sensitivity, recovery, and stability. No endogenous compounds were ...

angioedema is characterized by recurrent, circumscribed, solitary or multiple subcutaneous and mucosal swelling, involving the extremities, face, larynx, bowel wall. angioedema is due to hereditary or acquired varieties of c1 esterase inhibitor (c1inh) deficiency. a case of atypical acquired angioedema in a 49-year old man, responding favourably to cinnarizine and alcohol abstinence, is present...