This is the first report to identify the presence of chicoric acid (cichoric acid; also known as dicaffeoyltartaric acid, which is a caffeic acid derivatizedwith tartaric acid) in basil leaves. Rosmarinic acid, chicoric acid and caftaric acid (in the order of most abundant to least; all derivatives of caffeic acid) were identified in fresh basil leaves. Rosmarinic acid was themain phenolic comp...

Abstract One of the main purposes for which dandelions are cultivated is to derive phenolic acids from their processing. Phenolic acids, one useful compounds in dandelion, constitute important groups therapeutically significant bioactive traditional Chinese medicine. To carry out a relatively full evaluation dandelion quality, it was found advisable use multiple indices avoid conflict with sing...

Background & Aim: The genus Echinacea (family Asteraceae), commonly known as purple coneflower, is an important medicinal plant that has been used for centuries, customarily as a treatment for the common cold, coughs, bronchitis, upper respiratory infections, and some inflammatory conditions . The present study was carried out to evaluate the effect of six different methods of ...

Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased concentrations. Here, we elucidated role natural compound cichoric acid (CA) on MSU crystal-stimulated inflammatory response. The THP-1-derived macrophages (THP-Ms) were pretreated with CA then stimulated suspensions. protein levels p65 I?B?, activation NF-?B signalin...

Plant of genus Taraxacum known as dandelion have long been used in tradition medicinal. Extracts from dandelion possess anti-influenza virus, anti-fertility and anti-retrovirus activity, antioxidant and hepatoprotective effects. Chicoric acid also known as dicaffeyltartaric acid and belongs to phenylpropanoids is one of the main constituent of T. officinale. The current investigation was conduc...

Protein tyrosine phosphatase 1B (PTP1B), a major negative regulator of the insulin and leptin signaling pathway, is a potential target for therapeutic intervention against diabetes and obesity. The recent discovery of an allosteric site in PTP1B has created an alternate strategy in the development of PTP1B targeted therapy. The current study investigates the molecular interactions between the a...

Skin is the largest organ in the human body, and which protects organism against unfavorable external factors e.g., chemicals, environment pollutants, allergens, microorganisms, and it plays a crucial role in maintaining general homeostasis. It is also an important target of oxidative stress due to the activity of oxygen reactive species (ROS), which are constantly generated in the fibroblasts ...