RATIONALE Recent advances in analytical techniques have led to the development of gas chromatography/triple quadrupole mass spectrometry methods that allow the identification of target analytes in complex environmental samples. We have employed this technology to develop a method for characterizing alkylated chrysenes, which are environmental toxins that are resistant to weathering. METHODS A...

A method capable of determining 13 PAHs (acenaphthene, anthracene, benzo[a]anthracene, benzo[a]pyrene, benzo[b]fluoranthene, benzo[k]fluoranthene, chrysene, dibenzo[ah]anthracene, fluoranthene, fluorene, indene[1,2,3-cd]pyrene, phenanthrene and pyrene) in a mixture of 16 EPA PAHs by second derivative synchronous spectrofluorometry in the constant wavelength mode was developed. It has not been p...

The article by Smith et al. (1) in this issue of the Journal extends the elegant work of this group on mapping reaction sites of polycyclic aromatic hydrocarbon (PAH) diol epoxides and other activated carcinogens in the p53 tumor suppressor gene (also known as TP53) (2–4). Previously, these investigators (4) have shown that diol epoxides of benzo[a]pyrene (B[a]PDE) and benzo[g]chrysene, as well...

4 Isomeric polycyclic aromatic hydrocarbons (PAH) with two to six rings in coal-derived products and in a carbon black were separated, identified, and quantified by using capillary column gas chromatography and gas chromatography-mass spectrometry. A newly synthesized smectic liquid-crystalline polysiloxane and a conventional polymethylsiloxane were utilized as stationary phases. Many previousl...

Experiments were carried out to develop methods to generate well-characterized, polycyclic aromatic hydrocarbon (PAH)-spiked, aged but minimally altered sediments for fate, biodegradation, and bioavailability experiments. Changes in indigenous bacterial populations were monitored in mesocosms constructed of relatively clean San Diego Bay sediments, with and without exposure to gamma radiation, ...

Atmospheric particulate PAH concentrations were measured at two locations in Mumbai (formerly Bombay), India. Total PAH concentrations (seven compounds) at Saki Naka and Indian Institute of Technology (IIT) were 38.8 and 24.5 ng m~3. Pyrene and benz(a)anthracene#chrysene were abundant at both sites while benzo(b)#uoranthene and benzo(k)#uoranthene were abundant, in addition, at the IIT site. Th...

†̃ †̃bay-region' â€d̃iol-epoxides of PAH are important in their car cinogenic activity. A bay region occurs in PAH when an angu larly fused benzo ring is present (Chart 1). There is now direct evidence from tumorigenicity studies that bay-region diol epoxides of B(a)P (2, 14, 15, 22, 23) and BA (18, 25, 26) are ultimate carcinogenic metabolites. In addition, recent studies have shown that cert...

Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants. We have recently demonstrated that photoirradiation of PAHs leads to cytotoxicity, DNA damage, and induction of lipid peroxidation. In this paper we report the synthesis of all the six isomeric ethylchrysenes and the study of light-induced lipid peroxidation by these ethylchrysenes. 5-Ethylchrysene was sy...