The discovery of endothelin created a lot of enthusiasm and paved new therapeutic avenues for the treatment of arterial hypertension. Endothelin plays a significant role in blood pressure regulation through pronounced vasoconstriction and modulation of sodium and water reabsorption in the kidneys. Endothelin receptor antagonists have been tested in many clinical trials in patients with arterial...

Cardiovascular diseases represent a health problem. Among them, Systemic Arterial Hypertension (SAH) has high mortality rates, due to its consequences such as: Myocardial Infarction, heart failure, peripheral arterial disease, etc. In municipality in the southern forest of state Pernambuco, year 2020, rate chronic registered SIM program and E-SUS shows 67% hypertensive patients 13.47% these alr...

Hypertensive disorders of pregnancy (HDP) is one of the most important lethal complications in pregnant mothers. It is also associated with the subsequent development of chronic hypertension. The objective of this study was to identify the clinical risk factors of postpartum chronic hypertension in women diagnosed with HDP.Six hundred patients as HDP, who diagnosed and followed-up at least 6 mo...

pulmonary hypertension (ph) is an important cause of heart failure in chronic obstructive pulmonary disease (copd). the pro brain natriuretic peptide n-terminal (nt-probnp) has been suggested as a noninvasive marker to evaluate ventricular function. however, there is no evidence to support the use of nt-probnp in monitoring the benefits of vasodilators in copd induced ph. thus, we used nt-probn...

Chronic renal disease is frequently characterized by anemia, which may modify systemic and renal hemodynamics. In adult Munich-Wistar rats, the mild anemia (hematocrit, approximately equal to 42 vol/dl) that accompanies five-sixths nephrectomy was either made more severe (approximately equal to 30 vol/dl) by feeding a low iron diet or prevented (approximately equal to 50 vol/dl) by administrati...

By altering pre-glomerular resistance, healthy kidneys can maintain relatively stable glomerular capillary pressures despite variations in systemic blood pressure. This pressure regulatory process is termed “renal autoregulation”. Autoregulation can be reduced when renal disease results in loss of nephrons. Compromised autoregulation allows high systemic blood pressure to be transmitted to glom...

Tonic basal release of nitric oxide (NO) by vascular endothelial cells controls blood pressure (BP) in the basal state. In these studies we investigated the effects of chronic inhibition of basal NO synthesis in the rat for a 2-mo period. Significant systemic hypertension developed in chronically NO-blocked rats compared to controls. Marked renal vasoconstriction was also observed with elevatio...

The National High Blood Pressure Education Program's Working Group on High Blood Pressure in Pregnancy recently issued a report implicating hypertension as a complication in 6 to 8 percent of pregnancies. Hypertension in pregnancy is related to one of four conditions: (1) chronic hypertension that predates pregnancy; (2) preeclampsia-eclampsia, a serious, systemic syndrome of elevated blood pre...

Systemic arterial hypertension (SAH) is a chronic condition that highly prevalent worldwide. It occurs without symptoms in most individuals and represents the main modifiable risk factor for cardiovascular disease. The adoption of behaviors do not involve medication, such as changes lifestyle regular practice physical exercise, along with strict adherence to prescribed major challenge treatment...