Objective: Opioid dependence is a chronic and complex disorder characterized by relapse remission. Chronic administration of morphine causes symptoms physical psychological dependence. The purpose the present study was to investigate effect anti-addictive drugs such as bupropion varenicline on naloxone precipitated withdrawal syndrome in rat model. Materials Methods: To assess morphine, Wistar ...

Abstract* Introduction: Chronic morphine exposure can cause addiction and affect synaptic plasticity, but the underlying neural mechanisms of this phenomenon remain unknown. Herein we used electrophysiologic approaches in hippocampal CA1 area to examine the effect of chronic morphine administration on short-term plasticity. Methods: Experiments were carried out on hippocampal slices taken f...

A stable memory can be disrupted if amnestic treatment is applied in conjunction with memory reactivation. Recent findings in the conditioned place preference (CPP) model suggest that blocking reconsolidation attenuates the ability of environmental cues to induce craving and relapse in drug addicts, but the impact of prior physical dependence has not been described. We examined the effect of po...

Dopaminergic signaling in the basolateral amygdala (BLA) is important for drug-stimulus learning that triggers relapse to drug-seeking behavior. However, little is known about adaptive changes in this signaling pathway upon chronic morphine treatment. In this paper, we observed the influence of chronic morphine treatment on the effect of dopamine (DA) on the excitatory transmission in the pyram...

Introduction: There is some evidence supporting the reduced activity of integrins following chronic administration of morphine. This reduction might play a role in morphine tolerance development. Manganese binds to the extracellular domain of integrins and makes them to be activated. The effect of integrins activation using manganese on tolerance development to the analgesic effect of morphine ...

Morphine is one of the most types phenanthrene alkaloid opioid used to soothe acute and chronic pain via narcotic analgesic medical employment. Increasingly constantly in public medication practical important knowledge improve that. show pernicious has effects on numerous tissue for instance ovary, liver lung morphine side instruct existence oxidative role due generation reactive oxygen species...

Chronic opiate exposure leads to maladaptive changes in brain function. In view of the localization of opiate receptors in mammalian visual system, chronic opiate exposure is likely to affect the visual responses properties of V1 neurons. Using in vivo single-unit recording, we here showed that chronic morphine treatment resulted in the functional abnormality of primary visual cortical cells. W...

introduction: there are some evidences that the matricaria recutita extract has sedative effects and relieves symptoms of morphine withdrawal syndrome. symptoms of this syndrome are due to increased expression of fos transcription factor in brain. in this study the effect of chronic hydro alcoholic extract (30 mg/kg) of matricaria recutita on jumping behavior and expression of fos transcription...