نتایج جستجو برای: chronic lymphocytic leukemia cll
تعداد نتایج: 735072 فیلتر نتایج به سال:
Background and Aims: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Research has shown that in CLL, microRNAs can have function as oncogenes or tumor suppressors. Some studies demonstrated that the expression of microRNA-93 (miR-93) and microRNA-330 (miR-330) have been changed in several can...
Introduction: The rapidly expanding treatment landscape for Chronic Lymphocytic Leukemia (CLL) calls appropriate patient and selection sequencing with existing agents. Data describing CLL management are fragmented across different regions, marked cross-country differences in practices outcomes. Therefore, we have established the observational study CREEK, retrospective real-world evidence key d...
Cryptococcus neoformans is an encapsulated yeast that typically causes illness in immunocompromised hosts. Manifestations of the disease include pulmonary, Central Nervous System (CNS), and rare skeletal involvement. Optimal antifungal therapy for involvement has yet to be established. Here we present a potential regimen disseminated cryptococcal with pulmonary patient Chronic Lymphocytic Leuke...
Chronic Lymphocytic Leukemia (CLL) is one of the most common forms of adult leukemia in North Americans. However, it has been shown through the analysis of clinical studies and synopses of medical research that no current treatment indefinitely cures CLL or prolongs the life of CLL patients. Current CLL therapies are either symptomatic treatments (chemotherapy and immunotherapy) that do not imp...
Purpose:Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable disease. To establish the potential pathogenic role of miRNAs, the identification of deregulated miRNAs in CLL
Monoclonal B-Cell Lymphocytosis (MBL) is part of the mature B-cell neoplasms despite actually being a pre-neoplastic condition [1], this entity, largely unstudied, affects more than 5-10% older adults age 40 and incidence increases with aging [2,3], MBL widely associated as one main risk factors for developing Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphoma (SLL), since studies Prospecti...
Background: Coexistence of Chronic lymphocytic lymphoma (CLL) to Acute lymphoblastic leukemia is extremely rare with only a few reported cases [1-5]. Chronic lymphocytic leukemia is a neoplasm of small monomorphic round to irregularly shaped lymphocytes of B-cell lineage. Adverse prognostic factors in CLL include flow cytometric expression of ZAP-70 and CD38 which are surrogate markers for the ...
Standardized criteria for diagnosis and response assessment are needed to interpret and compare clinical trials and for approval of new therapeutic agents by regulatory agencies. Therefore, a National Cancer Institute-sponsored Working Group (NCI-WG) on chronic lymphocytic leukemia (CLL) published guidelines for the design and conduct of clinical trials for patients with CLL in 1988, which were...
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5-PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, ...
Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia, affects mostly elderly CLL patients, and is incurable without allogeneic transplantation. Although classic chemo(immuno)therapy is still the standard of care for patients in need of treatment, this paradigm might change in the near future with the advent of new therapeutic agents targeting major pathogenic pathways in CLL.
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