In general population about 15-20% of subjects have suffered from one episode of urticaria-angioedema syndrome in their life. The etiology of his condition is various and multifactorial. In children the principal cause of acute urticaria is infection, while physical factors are the main agents of chronic urticaria. All those conditions which lack an etiology are named chronic idiopathic urticar...

Background and purpose: Urticaria is a pruritic cutaneous disease characterized by weal and flare.  Acute and chronic urticaria affects the quality of life. Some abnormalities are associate or comorbid with urticaria. The purpose of this study was to examine comorbid conditions in patients with urticaria.  Materials and Methods: We searched in many databases including Google Scholar, PubMed, S...

Background: Chronic spontaneous urticaria is thought to occur due the patient's predilection produce self-reactions. Urticaria contributes loss of sleep, anxiety, depression, lack motivation and social isolation, which may contribute a substantial decrease in quality life. unpredictable can impair usual everyday activities. Autoimmune thyroid disorders are as consequence immune system dysregula...

BACKGROUND Autoimmune mechanisms are considered to play a significant role in chronic urticaria pathophysiology. Additionally, clinical experience emphasises the coexistence of chronic urticaria manifestation with thyroid autoimmunity. As the role of CTLA-4 polymorphism in autoimmune thyroid diseases is well proven we speculated on the possible role of this polymorphism in the background of chr...

Chronic urticaria, defined as widespread daily or nearly daily wheals for at least 6 weeks, with or without angioedema, impacts on patients’ quality of life. Natural course is self-limited, with spontaneous remissions and occasional relapses. Antihistamines, leukotriene inhibitor, immunosuppressive agents are used. 60% are idiopathic and 40% are autoimmune due to presence of anti-IgE antibody o...

Article type: Review Article Chronic urticaria is defined as a skin disease with central induration (wheal) and erythema formation around it (flare) that appears at least twice a week and remains at least for 6 weeks continually. The incidence of urticaria in children is about 0.1-3%. Most cases of chronic urticaria occur in children between 6-11 years. Autoimmune and allergy immaturity is one ...

introduction: auto – immune disorders have been implicated as a cause for chronic uricaria and/ or angioedema and thyroid autoimmunity has been increasingly introduced to be associated with that. this study explores the association of thyroid autoimmunity with chronic urticaria and / or angioedema in isfahani patients. methods: anti – thyroperoxidase (ani – tpo) and anti – thyroglobulin (anti –...

Chronic urticaria is now considered as an autoimmune disorder due to histamine-releasing autoantibodies in 40-50% of cases. These histamine releasing-autoantibodies directed against the high affinity IgE receptor or against IgE can be detected in vivo by autologous serum skin test (ASST) or in vitro by a functional assay employing basophils. ASST positivity has been found also in patients with ...