Objective(s) The main objective of this study was to investigate the status of chromosome stability in 3 human-mouse hybridoma cell lines over a period of time in various passages. Materials and Methods Metaphase spreads from 3 human-mouse cell lines (HF2X653, SPMO-4 and F3B6) that had been cultured in 4 successive passages, from 1 to 4 weeks, were prepared and analyzed. Metaphase chromosome...

the karyotype of zagros tooth-carp, aphanius vladykovi (coad) has been investigated byexamining metaphase chromosomes spreads obtained from gill epithelial and kidney cells. the diploidchromosome number of this species was 2n=48. the karyotype consisted of 8 submetacentric and 40subtelocentric chromosomes (8sm+40 st). the arm number (nf) was 28. sex chromosomes werecytologically indistinguishab...

found in iran, alburnoides bipunctatus and alburnus filippii. the chromosomes of these species were compared using giemsa staining and silver-staining (ag) techniques to describe the karyotypes. both species possess 2n = 50 chromosomes with no detected sex heteromorphism. the karyotypes were distinct, composed of 7 pairs of metacentric, 10 pairs of submetacentric, and 8 pairs of subtelo-acrocen...

background: oculocutaneous albinism type1 (oca1) is characterized by the absence of melanin pigmentation. the muta­tion on tyr gene makes oca1 as an autosomal recessive genetic disorder. in this study, we delineated the genetic analysis of an iranian family with four members affected with oca1.  methods: clinical exams and paraclinical test were performed for all patients of the case family, al...

in the present paper, the cytogenetic study including meiotic chromosome number and behavior along with pollen viability were performed in 4 populations of trigonella spruneriana boiss. this is the first cytogenetic report of the taxon. all populations are diploid and possess 2n = 2x = 16 chromosome number, which is consistent with the proposed basic number of x = 8. in addition, some meiotic i...

This study was conducted to determine the location of DNA segment with homology to the rat conserved genomic DNA in human chromosomes. The labeled rat genomic DNA was hybridized with normal human (male) metaphases. The study of 74 metaphases after fluorescence in situ hybridization showed 371 twin-spot signals on human chromosomes. Statistical analysis indicated that the specific accumulation o...

The rising global demand for palm oil and its associated products has led to increased numbers of palm oil refineries with its attendant effluent discharge. Many researches have confirmed the ecological disruptive potentiality of Palm Oil Mill Effluent (POME), still further attention has to be directed at POME’s potential genotoxicity. The present study has made physico-chemical and genotoxicit...