نتایج جستجو برای: cholinergic system
تعداد نتایج: 2245484 فیلتر نتایج به سال:
Acetylcholine is critically involved in modulating learning and memory function, which both decline in neurodegeneration. It remains unclear to what extent structural and functional changes in the cholinergic system contribute to episodic memory dysfunction in mild cognitive impairment (MCI), in addition to hippocampal degeneration. A better understanding is critical, given that the cholinergic...
Introduction: Recent findings revealed the biological effects of iron oxide nanoparticles on the central nervous system. Moreover, the brain cholinergic system plays a role in the modulation of anxiety behaviors. Therefore, this study aimed to evaluate the role of dorsal hippocampal muscarinic cholinergic receptors of the CA1 area on anxiety induced by iron oxide nanoparticles in adult male rat...
Introduction: Nitric Oxide is an important endogenous compound that acts as bronchodilator in trachea. Electromagnetic fields (EMF) affect nitric oxide level in different tissues. The interaction of nitrergic and cholinergic systems in airways has been reported. Therefore, the present study was performed to evaluate the interaction of cholinergic and nitrergic systems in the trachea of rats ...
a b s t r a c t alzheimer's disease (ad) is a neurodegenerative disorder in geriatric people that characterized by reduction in memory and learning ability. attenuation of cholinergic system is the most likely hypothesis. therefore, potentiation of the cholinergic system via inhibition of acetylcholinesterase enzyme could improve and alleviate the symptoms of ad. a new series of isatin-based ...
Background: Bone marrow stromal cells (BMSC) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. However, the transdifferentiation of BMSC into cholinergic phenotype requires more investigation. Methods: BMSC were isolated from adult rats, pre-induced with β-mercaptoethanol (BME) and followed by nerve growth factor (NGF) indu...
Background and purpose: Organophosphate (OP) compounds exert toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and overstimulation of the cholinergic system. Hyperactivity of brain cholinergic system can contribute to the pathophysiology of anxiety. The purpose of this study was to investigate the influence of repeated ex...
Schizophrenia is a severe psychiatric illness with a lifetime prevalence of ˜1% that imposes a huge toll on patients, their families and public health services worldwide. Delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior and negative symptoms constitute the core symptoms of schizophrenia. Although the neurotransmitter dopamine plays a prominent role in t...
Basal forebrain cholinergic neurons constitute a major neuromodulatory system implicated in normal cognition and neurodegenerative dementias. Cholinergic projections densely innervate neocortex, releasing acetylcholine to regulate arousal, attention, and learning. However, their precise behavioral function is poorly understood because identified cholinergic neurons have never been recorded duri...
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