Identification of recurrent cholesteatoma and differentiation from postoperative granulation tissue is important in a patient who has undergone mastoidectomy for cholesteatoma. We describe the diffusion-weighted imaging findings and apparent diffusion coefficient values in a case of recurrent cholesteatoma. This case suggests possible differentiation of cholesteatoma from granulation tissue on ...

OBJECTIVE To investigate and analyze the relationship between individual ossicular erosion and air-bone gap (ABG) among patients with cholesteatoma. STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. SUBJECTS AND METHODS Data from all patients undergoing an initial surgery for cholesteatoma were retrospectively reviewed to evaluate the relationships between preopera...

In order to provide much more understanding into the proliferation and differentiation of the epithelia in cholesteatoma, cell cycle associated molecules were studied by anti-PCNA and anti-Ki67, the two well characterized antibodies. In addition, The experiments included expression, localization, and quantification of EGF, TGF, EGF-R in the cholesteatoma. This study demonstrates the presence of...

OBJECTIVE To report on the value and limitations of new MRI techniques in pre- and post-operative MRI of cholesteatoma. The current value of magnetic resonance imaging (MRI) in diagnosing congenital, acquired, and post-operative recurrent or residual cholesteatoma is described. METHODOLOGY AND RESULTS High resolution computed tomography (HRCT) is still considered the imaging modality of choic...

UNLABELLED Bone destruction in chronic otitis media with cholesteatoma is a common phenomenon. Expanding growth of cholesteatoma in the middle ear causes ischemia of the mucosa and bones with granulation tissue production. THE AIM OF THIS STUDY was to assess the expression and distribution of the key regulators of bone destruction: osteoprotegerin (OPG), Receptor Activator for Nuclear Factor ...

To investigate whether keratinocytes proliferate in response to epiregulin produced by subepithelial fibroblasts derived from middle ear cholesteatoma. Tissue samples were obtained from patients undergoing tympanoplasty. The quantitative polymerase chain reaction and immunohistochemistry were performed to examine epiregulin expression and localization in cholesteatoma tissues and retroauricular...

OBJECTIVES/HYPOTHESIS High-resolution optical imaging is an imaging modality that allows visualization of structural changes in epithelial tissue in real time. Our prior studies using contrast-enhanced microendoscopy to image squamous cell carcinoma in the head and neck demonstrated that the contrast agent, proflavine, has high affinity for keratinized tissue. Thus, high-resolution microendosco...

Cholesteatoma is a benign keratinizing and hyper proliferative squamous epithelial lesion of the temporal bone. Epidermal growth factor (EGF) is one of the most important cytokines which has been shown to play a critical role in cholesteatoma. In this investigation, we studied the effects of EGF on the proliferation of keratinocytes and EGF-mediated signaling pathways underlying the pathogenesi...

Objective: To review the effect of learning curve on the audiological results of patients surgically treated for cholesteatoma. Study design: Retrospective review of patients records in tertiary referral center. Patients: Retrospective study of 758 patients operated by one surgeon for acquired middle ear cholesteatoma divided into two periods. The patients were divided into three age groups: ch...

INTRODUCTION AND AIMS the aim of this study was to determine the certainty of non-echo-planar imaging diffusion-weighted magnetic resonance imaging (non-EPI DW MRI) in the diagnosis of primary and recurrent cholesteatoma in patients with clinical suspicion of cholesteatoma, assessing the sensitivity and specificity of the test in both groups. METHODS Seventy-five patients with clinical suspic...