Chlorpromazine is a classical neuroleptic drug which produces both therapeutic effects as well as unwanted side effects in human such as sedation, autonomic, endocrine and neurological effects. It is thought that blockade of dopamine D-2 receptors caused by chlorpromazine induces these untoward side effects. Pre-clinical studies on catalepsy has been proposed as an animal model for neuroleptic ...

in the present study histological studies was conducted after the female abramis brama orientalis was exposed to eight treatment phases in which lhrha2 (3 μg/kg), metoclopramide (5 mg/kg), and chlorpromazine (10 mg/kg) were inoculated. the treatments were characterized by combined and solitary injections, control group (o injection), and experimental group (saline). the results showed that all ...

In the previous paper (Dawkins, Judah & Rees, 1959) it was shown that 10-(3-dimethylaminopropyl)-2-chlorophenothiazine (chlorpromazine) was an inhibitor of cytochrome oxidase and also exhibited some action against oxidative phosphorylation. During the course of this investigation, it became apparent that chlorpromazine also had a second point of action in the respiratory chain. This paper descr...

OBJECTIVE To establish whether there is any difference in the efficacy of a chlorpromazine regimen and a sumatriptan regimen for the management of the pain of acute severe migraine. SETTING Two urban teaching hospital emergency departments. METHODS Prospective, randomised, unblinded, crossover trial. All patients received intravenous metoclopramide 10 mg and 1000 ml of normal saline over 1 ...

Antipsychotic drugs are widely used to alleviate a number of psychic disorders and have been found to modulate some immune parameters, but the molecular mechanism of their action on the proliferative activity has been poorly recognized. In the present study, we investigated effects of various antipsychotics on the proliferative activity of lymphocytes stimulated by concanavalin A (Con A) and li...

An experiment was carried out to evaluate the serum total protein, glucose, liver, kidney and haematological response varied levels of exogenous L-Selenomethionine (L-SeMet). Twenty four male rabbit bucks, about 10 months old were randomly allotted treatments in a completely randomized design. Blood samples collected at day 21 42 from bucks processed for haematocrit, haemoglobin, erythrocytes, ...

Owing to the importance of clean and fertile agricultural soil for the continued existence of man, this study investigated the concentrations of total petroleum hydrocarbons (TPHs), polycyclic aromatic hydrocarbons (PAHs) and some heavy metals in soils and selected commonly consumed vegetables and tubers from oil-polluted active agricultural farmland in Gokana of Ogoniland, Rivers State, Nigeri...

Estrogen deficiency was produced in female Sprague-Dawley rats by surgical removal of both the ovaries and these animals were used 4 weeks later. Endothelium-dependent and endothelium-independent relaxations due to acetylcholine and sodium nitroprusside were observed respectively, in isolated rat thoracic aortic ring preparation. Extent of lipid peroxidation was measured by estimating serum TBA...

OBJECTIVE The purpose of this study was to compare the efficacy of olanzapine with that of chlorpromazine plus benztropine in patients with treatment-resistant schizophrenia. METHOD One hundred three previously treatment-resistant patients with schizophrenia diagnosed according to the DSM-III-R criteria were given a prospective 6-week trial of 10-40 mg/day of haloperidol. Eighty-four of them ...

Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyroid hormone stimulation of kidney preparations was not inhibited under these c...