Chlorpromazine is known to cause ocular pigmentary deposits. However, delayed presentation after cessation of chlorpromazine has not been reported. There are also no reports on whether newer generation of anti-psychotic agents contribute to ocular toxicity. We describe a case of ocular toxicity related to anti-psychotic agents. To the best of our knowledge, this is the first reported case of an...

BACKGROUND Chlorpromazine is a dopamine-receptor antagonist antipsychotic agent. Because of its strong alpha-blocking and sedative actions, it has also been used as emergency therapy for extreme arterial hypertension. Published reports to date have included very small numbers of patients (i.e., 5-30). OBJECTIVES To analyze data on almost 500 patients who received intravenous chlorpromazine fo...

Two newly isolated mutant strains of Neurospora crassa, cpz-1 and cpz-2, were hypersensitive to chlorpromazine with respect to mycelial growth but responded differently to the drug with respect to the circadian conidiation rhythm. In the wild type, chlorpromazine caused shortening of the period length of the conidiation rhythm. Pulse treatment with the drug shifted the phase and inhibited light...

IN the original publication on chlorpromazine, Courvoisier and her associates (1953) reported that this phenothiazine potentiated the intensity and duration of action of analgesic drugs in animals. They did not, however, show that chlorpromazine itself possessed any analgesic action. Schneider (1954) also found that it increased the duration of morphine analgesia in mice. Kopera and Armitage (1...

Chlorpromazine, a widely used tranquilizing drug of the phenothiazine group, was found to be a very potent photochemical inactivator of both deoxyribonucleic acid and ribonucleic acid viruses in the presence of long-wave ultraviolet light (320 to 380 nm). Neither the light alone nor chlorpromazine alone caused any appreciable inactivation. The known chlorpromazine photoreactions with nucleic ac...

The tumor-initiating ability of Agrobacterium tumefaciens was enhanced two- to threefold after a preinoculation exposure to the phenothiazine derivative chlorpromazine hydrochloride. The mean number of tumors initiated per viable bacterium on pinto bean leaves was greatest after a 1-hr exposure to 15 mug of the drug per ml. Chlorpromazine had no significant effect on tumor initiation when appli...

in the present study histological studies was conducted after the female abramis brama orientalis was exposed to eight treatment phases in which lhrha2 (3 μg/kg), metoclopramide (5 mg/kg), and chlorpromazine (10 mg/kg) were inoculated. the treatments were characterized by combined and solitary injections, control group (o injection), and experimental group (saline). the results showed that all ...

caspian kutum, rutilus frisii kutum, is one of the most commercially important fish species in the caspian sea, but there are few reports about the endocrinology of induced spawning in this fish. in the present study, 54 individuals of female broodstocks of kutum were studied for quantity and quality of propagation index, during march and april 2007. hormone treatments include: lhrh-a2 (1 ?g kg...

synthetic lhrha or its superactive analogues stimulate gth release. it shows an overlap in the biological activity of lhrha and gnrh in many teleost species. the aim of the present study was to investigate the effects of lhrha2, metoclopramide and chlorpromazine on hpg axis and plasma levels of ght ii. luteinizing hormone releasing hormone analogue 2 (lhrha2) (3 mg/kg) with dopamine antagonis’s...

Objectives: The aim of this study was to investigate the prevalence and its determinants of Antipsychotic Use in patients with psychiatric disorders. Materials and Methods: This study was on patients with psychiatric disorder that have discharged from the hospital. We have assessed all patients with psychiatric interview and evaluation of their psychiatric documentations. Results: 90.7% o...