Data from our present studies demonstrate the capability of a 105,000 x g pellet from rat normal bone marrow, turpentine-induced hyperplastic bone marrow, and chlo roma tumor to transform precursor arachidonic acid into prostaglandmns. The activity of the prostaglandin synthetase systems in these tissues is inhibited by the known nonster oid antiinflammatory drug indomethacin and by two unsat u...

Localized tumors composed of immature cells of the myelogenous series have been recognized for many years as an uncommon manifestation of granulocytic leukemia. The histologic diagnosis of chloroma (granulocytic sarcoma) may be extremely difficult when the myeloblastic cells are poorly differentiated and the tumor lacks the characteristic green color. The diagnostic difficulty may be further co...

Localized tumors composed of immature cells of the myelogenous series have been recognized for many years as an uncommon manifestation of granulocytic leukemia. The histologic diagnosis of chloroma (granulocytic sarcoma) may be extremely difficult when the myeloblastic cells are poorly differentiated and the tumor lacks the characteristic green color. The diagnostic difficulty may be further co...

Granulocytic sarcoma (chloroma) is an unusual tumor composed of primitive cells of the myeloid series. It occurs in younger patients with acute myelogenous leukemia. The lesions present grossly as solid, greenish tumors composed of primitive precursor cells of the granulocytic series. Chloroma refers to the greenish color of the tumor, which can be attributed to the myeloperoxidase in the tumor...