The early description of cystic fibrosis (CF) dates back to late 30s. In 1936, Fanconi identified the association between the “congenital CF of the pancreas and broncheactasis" shortly followed by Andersen who in 1938 gave the complete anatomopathologic description of CF. In 1953, Di Sant'Agnese described an excess of sodium chloride in the sweat of children affected by CF. This discovery short...

The hypothesis examined in this study is that iodide reabsorption is chiefly passives occurring in the same portions of the nephron as the reabsorption of chloride and other small monovalent anions, with the ratio of the permeability of the tubule to iodide to its permeability to chloride a constant. If this were true, iodide clearance and chloride clearance would be interrelated in a uniform m...

The early description of cystic fibrosis (CF) dates back to late 30s. In 1936, Fanconi identified the association between the “congenital CF of the pancreas and broncheactasis" shortly followed by Andersen who in 1938 gave the complete anatomopathologic description of CF. In 1953, Di Sant'Agnese described an excess of sodium chloride in the sweat of children affected by CF. This discovery short...

Although Beadle a9 early as 1937 suggested that the urine of Nereis diversicolor O. F. Miiller might be of lower concentration than the body fluids when this worm is hyperregulating in low salinities, there has been no direct measurement of urine concentration to support this reasonable idea. Jorgensen & Dales (1957) studied osmotic water uptake and loss in N. diversicolor and calculated that t...

The early proximal tubule preferentially reabsorbs organic solutes and bicarbonate over chloride ions resulting in a luminal fluid with a higher chloride concentration than that in blood. From this late proximal tubular fluid, half of NaCl reabsorption by the adult proximal tubule is active and transcellular and half is passive and paracellular. The purpose of the present in vitro microperfusio...

Self-compacting concrete (SCC) is one of the most significant advances in concrete technology in the last two decades. SCC was developed to ensure adequate compaction through self-consolidation and facilitate placement of concrete in structures with congested reinforcement and in restricted areas. Marble Sludge Powder (MSP) can be used as filler and helps to reduce the total voids content in co...

A research program was carried out to evaluate the chloride ion permeability of both air and non-air entrained concretes made with mineral admixtures as partial replacements of cement. Two series of investigations (Series 1 and Series 2) were carried out. The mixtures were proportioned to have 28-day strengths of 35 MPa for Series 1 and 69 MPa for Series 2. Chloride ion permeability was determi...

Influence of pH, buffer, preservative, tonicity and viscosity modifiers on in vitro transcorneal permeation of ofloxacin was studied using excised goat cornea. Permeation studies were carried out by putting 1 ml of test formulation on the cornea (0.78cm) mounted between the donor and receptor compartments of an all glass modified Franz diffusion cell and measuring ofloxacin concentration in the...

In excitable cells, the generation of an action potential (AP) is associated with transient changes of the intra- and extracellular concentrations of small ions such as Na(+), K(+) and Cl(-). If these changes cannot be fully reversed between successive APs cumulative changes of trans-membrane ion gradients will occur, impinging on the cell volume and the duration, amplitude and frequency of APs...