AIM The aim of the study was to evaluate the effect of addition of 1% chlorhexidine digluconate solution on the antibacterial activity and mechanical properties of glass ionomer and resin based sealant. MATERIALS AND METHODS Conventional glass ionomer sealant (GIS) (Fuji VII, Japan) and resin sealant (Clinpro 3M ESPE, USA) were used in this study. Chlorhexidine digluconate (CHX) (20%) liquid ...

Achieving increased access to medicines in low- and middle-income countries is a complex issue that requires a holistic approach. Choosing an appropriate manufacturing strategy that can ensure a sustainable supply of these medicines is an essential component of that approach. The Chlorhexidine Working Group, a consortium of more than 25 international organizations, donors, and manufacturers led...

Periodontal diseases are a diversified group of clinical entities, described as pathologies of a multifactorial nature, in which the induction of an inflammatory process that destroys the fixation apparatus, loss of the alveolar bone and, if untreated, in the loss of the dental element. Among the wide variety of drugs used in the treatment of periodontal disease, chlorhexidine demonstrated to b...

BACKGROUND Chlorhexidine is used for disinfection of skin and mucosae in medicine and dentistry. Prolonged exposure may lead to contact sensitization and allergic contact dermatitis or stomatitis. OBJECTIVES The purpose of this study was to analyse the sources of chlorhexidine exposure and sensitization, and to obtain data on the prevalence of sensitization and chlorhexidine-related contact a...

BACKGROUND Chlorhexidine digluconate (CHG) is a widely used skin antiseptic, however it poorly penetrates the skin, limiting its efficacy against microorganisms residing beneath the surface layers of skin. The aim of the current study was to improve the delivery of chlorhexidine digluconate (CHG) when used as a skin antiseptic. METHOD Chlorhexidine was applied to the surface of donor skin and...

BACKGROUND Recent trials in Bangladesh, Nepal, and Pakistan have shown that chlorhexidine is an effective antiseptic for umbilical cord care compared to existing community-based cord care practices. Because of the aggregate reduction in neonatal mortality in these trials, interest is high in introducing a 7.1% chlorhexidine digluconate liquid or gel that delivers 4% chlorhexidine for umbilical ...

background: multi-specie biofi lms are highly resistant to antimicrobials due to cellular interactions found in them. the purpose of this study was to evaluate, by confocal laser scanning microscopy, the biofi lm dissolution effectiveness of different irrigant solutions on biofi lms developed on infected dentin in situ. materials and methods: a total of 120 bovine dentin specimens infected intr...