This study attempted to develop chitosan-based nanoparticles with increased stability and antibacterial activity. The chitosan/protamine hybrid nanoparticles were formed based on an ionic gelation method by mixing chitosan with protamine and subsequently cross-linking the mixtures with sodium tripolyphosphate (TPP). The effects of protamine on the chemical structures, physical properties, and a...

Chitosan nanoparticles, such as those prepared in this study, may exhibit potential antibacterial activity as their unique character. The purpose of this study was to evaluate the in vitro antibacterial activity of chitosan nanoparticles and copper-loaded nanoparticles against various microorganisms. Chitosan nanoparticles were prepared based on the ionic gelation of chitosan with tripolyphosph...

This paper describes a method for preparing chitosan fibers modified with hydroxyapatite (HAp), tricalcium phosphate (β-TCP), and HAp/β-TCP nanoparticles. Fiber-grade chitosan derived from the northern shrimp (Pandalus borealis) and nanoparticles of tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) suspended in a diluted chitosan solution were used in the investigation. Diluted chitosan sol...

in this study, fe 3 o 4 superparamagnetic nanoparticles were synthesized and stabilized by chitosan. then the nanoparticles were characterized by fourier transform infrared spectroscopy and transmission electron microscopy (tem). particle size distribution and zeta potential of the particles also was assessed using malvern zetasizer. the paramagnetic behaviors of the uncoated and chitosan coate...

Chitosan, a natural biodegradable polymer is recommended for development of nanoparticles intended for chronic infection such as tuberculosis. Formulation and processing variables play a critical role in the formation of nanoparticles prepared with chitosan. The present study investigated the influence of polymer (chitosan) molecular weight, stabilizing agent (tween 80) concentration and stirri...

bioedegradable nanoparticles are intensively investigated for their potential applications in drug delivery systems. being a biocompatible and biodegradable polymer, chitosan holds great promise for use in this area. this investigation was concerned with determination and optimization of the effective parameters involved in the production of chitosan nanoparticles using ionic gelation method. s...

Background: Curcumin as a yellow natural compound extracted from turmeric root is known it as an antibacterial agent. One of the nanoparticles ability is to decrease the defects of usual drug delivery systems. Chitosan is a low toxic, biodegradable, biocompatible and safe polymer which is used in production of nanoparticles. Nanoparticles like chitosan-tripolyphosphate (TPP) are able to increas...

Background: Chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. The aim of the present study is to synthesis and optimization of chitosan nanoparticles for industrial and biomedical applicati...

The purpose of the present study was to evaluate the neuroprotective efficacy of optimized thymoquinone loaded PLGA-chitosan nanoparticles delivered via nose to brain route in the rodent cerebral ischemia-reperfusion model. The neuroprotective efficacy of the optimized thymoquinone loaded PLGA-chitosan nanoparticles was evaluated in middle cerebral artery occluded rats by various pharmacodynami...

BACKGROUND AND THE PURPOSE OF THE STUDY Studies show that chitosan nanoparticles increase mucoadhesivity and penetration of large molecules across mucosal surface. The aim of the present study was to investigate the use of thiolated chitosan in the development of polysaccharide-coated nanoparticles in order to confer specific functionality to the system. METHODS Methyl methacrylate nanopartic...