Metabolomics is the “omics” that studies the whole metabolome. It has a wide range of applications, inter alia chemotaxonomy, environmental influences, agriculture, etc. Here we review the application of metabolomics in natural product research. The importance of physicochemical properties to drug delivery are discussed in relation to turning metabolomic studies towards drug discovery. We belie...

Volatile profiles yielded from gas chromatography-mass spectrometry (GC-MS) analysis provide abundant information not only for metabolism-related research, but also for chemotaxonomy. To study the chemotaxonomy of Mangshanyegan, its volatile profiles of fruit and leaf and those of 29 other genotypes of Citrus, Poncirus, and Fortunella were subjected to phylogenetic analyses. Results showed that...

Chemotaxonomy and the comparative analysis of metabolic features of fungi have the potential to provide valuable information relating to ecology and evolution, but have not been fully explored in fungal biology. Here, we investigated the chemical diversity of legume-associated Ascochyta and Phoma species and the possible use of a metabolomics approach using liquid chromatography-mass spectromet...

The existing taxonomy of oral treponemes is not satisfactory. This is due to the fact that these strict anaerobic bacteria are not easily cultivated or differentiated. Therefore, new techniques that can contribute to improved cultivation, classification, and identification of these fastidious organisms should be welcomed. In the present study capillary zone electrophoresis (CZE) was used to dis...

Centrosema, Phytoalexins, Isoflavones, Tectorigenin, Aesculetin, Chemotaxonomy A phytoalexin isolated from the fungus-inoculated leaflets of Centrosema haitiense, C. pubescens (3 accessions) and C. virginianum has been identified as 5,7,4'-trihydroxy-6-methoxyisoflavone (tectorigenin). This compound is variously accompanied by other isoflavones includ­ ing the previously described phytoalexin, ...

Convallaria accompanied the scientific work of Prof. Kubelka through all these years, resulting in the Habilitation for Pharmacognosy in 1973. He is author of more than 100 publications dealing, for example, with the isolation and characterization of plant constituents, development of analytical methods suitable for the proof of quality of herbal substances and herbal preparations, biosynthesis...

BACKGROUND Morus alba has long been used in traditional Chinese medicine to treat inflammatory diseases; however, the scientific basis for such usage and the mechanism of action are not well understood. This study investigated the action of M. alba on leukocyte migration, one key step in inflammation. METHODS Gas chromatography-mass spectrometry (GC-MS) and cluster analyses of supercritical C...

In this study, seven Trichoderma species (33 strains) were classified using secondary metabolite profile-based chemotaxonomy. Secondary metabolites were analyzed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS-MS) and multivariate statistical methods. T. longibrachiatum and T. virens were independently clustered based on both internal transcribed spacer (ITS...