Cryptococcus neoformans is the only encapsulated human-pathogenic fungus and a facultative intracellular pathogen that can reside in macrophages without host cell lysis. In the present study, we investigated how phagocytosis of C. neoformans affected the macrophage response to chemoattractants such as fractalkine (FKN) (CX3CL1) and colony-stimulating factor 1 (CSF-1). Phagocytosis of immunoglob...

Various authors have associated increased susceptibility to infectious diseases in certain patients to inhibitors of neutrophil chemotaxis demonstrable in serum or diluted plasma of these patients. The present experiments showed, however, that serum and diluted plasma but not undiluted plasma from normal human donors consistently inhibited chemotactic migratiQn of autologous human neutrophil gr...

Address for Correspondence: Dr. Prabhakar Patil, Navodaya Medical College, Raichur, Karnataka, India. Mobile No. +919900346851. E-Mail: [email protected] Access this Article online Quick Response code Web site: 1,*3,4,5 Navodaya Medical College Raichur, Karnataka, India. 2 R.C. Patel College of Pharmacy, Shirpur, Dhule, Maharashtra, India. The objective of present study was to investigate...

An innate immune cell can sense a pathogen, either from a distance by recognizing chemoattractant stimuli or by direct physical contact. The pathogen is subsequently neutralized, which usually occurs through its phagocytic internalization. By investigating chemotaxis and phagocytosis from an immunophysical single-cell perspective, it now appears that the demarcation between these two processes ...

Coronins are a family of conserved actin-associated proteins that have been implicated in a variety of cellular processes dependent on actin rearrangements. In this study, we show that in primary human neutrophils, coronins-1-4 and -7 are expressed. Coronin-1 accumulates at the leading edge of migrating neutrophils and at the nascent phagosome. Inhibition of coronin function by transduction of ...

Background Association of neutrophil function abnormalities with localized aggressive periodontitis (LAP) has been reported in Indian population. There are no published studies on the familial aggregation of aggressive periodontitis (AP) and neutrophil function abnormalities associated with it in Indian population. The present study aimed to assess neutrophil chemotaxis, phagocytosis, and micro...