Chemotaxis is a cellular response that directs cell migration toward a chemical gradient and is fundamental to a variety of cellular processes. The receptors for most known chemokines belong to the seven transmembrane-spanning superfamily and signal through members of the G(alphai) family. Beta-arrestins, in addition to regulating desensitization, have emerged as potential mediators of G-protei...

Aspects of innate immunity derive from characteristics inherent to phagocytes, including chemotaxis toward and engulfment of unicellular organisms or cell debris. Ligand chemotaxis has been biochemically investigated using mammalian and model systems, but precision of chemotaxis towards ligands being actively secreted by live bacteria is not well studied, nor has there been systematic analyses ...

In this paper we develop a field-theoretic description for run and tumble chemotaxis, based on density functional of crystalline materials modified to capture orientational ordering. We show that framework, with its in-built multi-particle interactions, soft-core repulsion elasticity is ideal describing continuum collective phases particle resolution, but diffusive timescales. our model exhibit...

Alveolar macrophages produce neutrophil chemoattractants; this cellular cross-talk contributes to neutrophilic airway inflammation in chronic obstructive pulmonary disease (COPD). We have investigated the chemotaxis cross-talk mechanisms between these cells using COPD alveolar macrophages. Using conditioned media from stimulated COPD alveolar macrophages, we investigated the relative contributi...

We examine a general model for the Fisher-KPP (FKPP) equation with nonlocal advection. The main interpretation of this is as describing diffusing and logistically growing population that also influenced by intraspecific attraction or repulsion. For particular choice parameters, specializes to Keller-Segel-Fisher chemotaxis. Our interest in effect chemotaxis on speed traveling waves. prove there...

Keller-Segel equations are widely employed to explain chemotaxis-induced bacterial traveling band phenomena. In this system, the dispersal of bacteria is modeled by independently given diffusion and advection terms, growth cell population neglected. paper, we develop a chemotaxis model which consists cross-diffusion growth. particular, consider case that terms form an exact cross-diffusion. The...

Escherichia coli and Salmonella typhimurium show positive chemotaxis to glycerol, a chemical previously reported to be a repellent for E. coli. The threshold of the attractant response in both species was 10(-6) M glycerol. Glycerol chemotaxis was energy dependent and coincident with an increase in membrane potential. Metabolism of glycerol was required for chemotaxis, and when lactate was pres...

Polymorphonuclear leukocyte (PMNL) chemotaxis studies of 32 patients with localized juvenile periodontitis (periodontosis or LJP), 10 adult patients with a history of LJP (post-LJP), 8 patients with generalized juvenile periodontitis (GJP), and 23 adults with moderate to severe periodontitis were performed: (i) to determine the prevalence of a PMNL chemotaxis defect in a large group of LJP pati...